Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Protection of phenylhydrazine-induced hematotoxicity by aqueous extract of Ocimum basilicum in Wistar male rats

Thu Dec 8 22:19:27 2022

(2019) Protection of phenylhydrazine-induced hematotoxicity by aqueous extract of Ocimum basilicum in Wistar male rats. Comparative Clinical Pathology. pp. 331-338. ISSN 16185641 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

In recent years, Iranian traditional medicine has been used to treat various diseases such as anemia. One of these plants is Ocimum basilicum L. In this experiment, we evaluated the anti-anemia and antioxidant properties of aqueous extract of O. basilicum in phenylhydrazine-induced anemic rats. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging test was used to examine the antioxidant property of O. basilicum aqueous extract, which indicated high antioxidant property compared to butylated hydroxytoluene (BHT) as the positive control. In vivo design, after 1 day of the last injection of phenylhydrazine, the rats were divided into five subgroups, including negative healthy control, untreated negative control, and three groups receiving the O. basilicum at 20, 60, and 180 mg/kg concentrations. At the end of day 15 of treatment, the animals of all groups were euthanized and blood samples were drawn immediately from the animals’ hearts to analyze the hematological and biochemical parameters. The data were analyzed by SPSS-21 software. Several doses of O. basilicum (especially O180) significantly (p ≤ 0.05) enhanced the levels of body weight, WBC, neutrophils, monocytes, platelet, RBC, Hb, PCV, MCV, MCH, MCHC, and reduced the raised levels of ALP, AST, ALT, GGT, urea, creatinine, ferrous, ferritin, and erythropoietin as compared to the untreated group. In conclusion, the obtained results revealed the anti-anemia and antioxidant properties of aqueous extract of O. basilicum. Extraction of active molecules will be the future work to peruse. © 2018, Springer-Verlag London Ltd., part of Springer Nature.

Item Type: Article
Creators:
CreatorsEmail
Zangeneh, M. M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Salmani, S.UNSPECIFIED
Jamshidpour, R.UNSPECIFIED
Kosari, F.UNSPECIFIED
Keywords: Anti-anemia potential Aqueous extract Ocimum basilicum
Divisions:
Page Range: pp. 331-338
Journal or Publication Title: Comparative Clinical Pathology
Journal Index: Scopus
Volume: 28
Number: 2
Identification Number: https://doi.org/10.1007/s00580-018-2845-8
ISSN: 16185641 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3811

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