Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Comparison of ocular characteristic between major thalassemia and healthy group

Fri May 24 11:29:54 2024

(2021) Comparison of ocular characteristic between major thalassemia and healthy group. Acta Medica Iranica. pp. 603-609. ISSN 00446025 (ISSN)

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To determine and compare ocular characteristics and refractive errors between major thalassemia patients and normal subjects. In this study, 71 thalassemia major patients and 79 age and sex-matched healthy subjects that were selected in an ongoing manner underwent complete optometric and ophthalmic examinations, including autorefraction, subjective refraction, fluorescein tear break-up time, and pachymetry after anthropometric measurements. The results showed that the mean UCVA was better in the control group versus the thalassemia group (P<0.001), while there was no difference in BCVA between the two groups (P=0.416). Moreover, the mean spherical equivalent was 0.38±0.13 D less in the thalassemia group compared to the control group (P=0.007), while corneal power (P<0.001) and cylinder power (P=0.001) were larger in thalassemia patients. The most common type of astigmatism was against the rule pattern in thalassemia patients and with the rule pattern in the control group (P<0.001). The mean tear break-up time was 11.35±6.43 in the thalassemia group and 14.63±5.79 in the control group (P=0.001), and the mean near the point of accommodation (NPA) (P=0.009) and near the point of convergence (NPC). (P=0.003) were significantly smaller in the thalassemia group compared to the control group. These patients suffer from a myopic shift due to exaggerated responses to changes in ocular growth, dry eye secondary to goblet cell loss, and a higher prevalence of vertical astigmatism due to eyelid laxity and pressure on the cornea. Therefore, regular ophthalmological evaluations are highly recommended in these patients. © 2021 Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Koochakzadeh, L.UNSPECIFIED
Ostadimoghaddam, H.UNSPECIFIED
Khabazkhoob, M.UNSPECIFIED
Keywords: Beta-thalassemia Cohort study Ocular characteristic Refractive errors ferritin fluorescein hemoglobin sodium chloride adolescent adult anthropometry Article astigmatism best corrected visual acuity binocular convergence blinking blood transfusion body mass bulbar conjunctiva cell loss chelation therapy cohort analysis controlled study cornea corneal endothelial cell loss diplopia dry eye emmetropia eye refraction female ferritin blood level goblet cell hemoglobin blood level human hypermetropia intraocular pressure keratometry local anesthesia major clinical study male myopia ophthalmology optometry pachymetry prevalence refraction error refractometry retinoscopy slit lamp microscopy stopwatch tear break-up time thalassemia thalassemia major visual acuity
Page Range: pp. 603-609
Journal or Publication Title: Acta Medica Iranica
Journal Index: Scopus
Volume: 59
Number: 10
Identification Number:
ISSN: 00446025 (ISSN)
Depositing User: مهندس مهدی شریفی

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