Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Development of rheumatoid arthritis by toxoplasmosis in Iranian patients

Tue Aug 16 11:13:29 2022

(2021) Development of rheumatoid arthritis by toxoplasmosis in Iranian patients. Journal of Kerman University of Medical Sciences. pp. 412-419. ISSN 10239510 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Toxoplasma gondii (T. gondii) is an intracellular protozoan parasite capable of infecting approximately one-third of the world human population. In this study, the seroprevalence of Toxoplasma gondii (T. gondii) antibodies in Iranian patients with rheumatoid arthritis was investigated, given the lack of information on the magnitude of toxoplasmosis in these patients. Methods: The serum was collected from patients with rheumatoid arthritis (n = 93) and a healthy control group (n = 93) from central parts of Iran to investigate the prevalence of anti-T. gondii IgG and IgM antibodies. Results: Anti-T. gondii IgG was detected among 76 of 93 patients with rheumatoid arthritis (81.72) versus 37 of 93 healthy control group (39.80), and it was higher among patients with rheumatoid arthritis than controls. The seroprevalence of anti-T. gondii IgM was significantly higher in patients with rheumatoid arthritis (36 of 93; 38.70) compared to the healthy control group (2 of 93; 2.1). Demographic variables (age and sex) did not have significant correlations in patients with rheumatoid arthritis who were positive for T. gondii infection. Conclusion: The findings of the present study provide efficient evidence that confirm the association between toxoplasmosis and development of rheumatoid arthritis, suggesting that Toxoplasma may contribute to the rheumatoid arthritis pathogenesis. © 2021, Kerman University of Medical Sciences. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Masoori, L.UNSPECIFIED
Molazadeh, M.UNSPECIFIED
Rezaei, N.UNSPECIFIED
Alizadeh, S.UNSPECIFIED
Hassanpour, H.UNSPECIFIED
Badirzadeh, A.UNSPECIFIED
Keywords: Autoimmunity Immune system Iran Rheumatoid arthritis Toxoplasma gondii antinuclear antibody C reactive protein cyclic citrullinated peptide antibody immunoglobulin M rheumatoid factor Article blood cell count blood sampling case control study controlled study disease severity enzyme linked immunosorbent assay erythrocyte sedimentation rate female human immunofluorescence Iranian (citizen) latex agglutination test major clinical study male questionnaire reactive arthritis seroprevalence Toxoplasma toxoplasmosis
Divisions:
Page Range: pp. 412-419
Journal or Publication Title: Journal of Kerman University of Medical Sciences
Journal Index: Scopus
Volume: 28
Number: 4
Identification Number: https://doi.org/10.22062/JKMU.2021.91724
ISSN: 10239510 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3786

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