Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Identifying the Lowest Effective Initial Dose of Prednisolone for the Treatment of Subacute Granulomatous Thyroiditis: A Systematic Review and Meta-Analysis

Tue Aug 16 11:00:50 2022

(2021) Identifying the Lowest Effective Initial Dose of Prednisolone for the Treatment of Subacute Granulomatous Thyroiditis: A Systematic Review and Meta-Analysis. Current reviews in clinical and experimental pharmacology. ISSN 2772-4336 (Electronic) 2772-4328 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/34636318

Abstract

BACKGROUND: Subacute granulomatous thyroiditis (SAGT) is an inflammatory disease due to viral infections. Glucocorticoids, especially prednisolone (PSL), are one of the first approaches in the treatment of patients with SAGT. To date, no study has determined the lowest effective dose of prednisolone with the lowest recurrence rate in the treatment of SAGT. This study aimed to use meta-analysis methods to identify the appropriate dosage of prednisolone with the lowest recurrence rate in the treatment of patients with SAGT. METHODS: This study was conducted according to the PRISMA checklist in February 2021. Two independent researchers performed a search for relevant literature published before March 2021 in English databases including Scopus, MEDLINE (via PubMed), Web of Science, Cochrane Library, Google Scholar, EMBASE, and also Persian electronic databases including SID, Iran medex, Magiran, and Irandoc. The search algorithm was initially developed by using a combination of MeSH terms, keywords, and also Boolean operators ("AND"; "OR"; "NOT"): Subacute thyroiditis, De Quervain Thyroiditis, Glucocorticoids, Prednisolone, Recurrence, and Meta-Analysis. All statistical analyses were performed using STATA 15.0 (StataCorp LLC, College Station, TX, USA) and SPSS 17.0. A random-effects model based on Metaprop were applied for the Meta-analysis. To assess heterogeneity between studies, the chi-squared test and I2 index were used, and for evaluating publication bias, funnel plots and Egger tests were performed. RESULTS: The overall recurrence rate was 14.72 95% CI: 9.63- 20.58 and there was a significant heterogeneity among the studies I2 = 69.56%; P=0.000. To evaluate the lowest effective dose of prednisolone, we divided the studies into two groups based on the mean initial dose of prednisolone: less than or equal to 20 mg/day (group one) and greater than 20 mg/day (group two). The recurrence rate in group 1 was 11% 95% CI: 5.7- 16.2 and in group 2 was 23.6% 95% CI: 11.5- 35.6. Significant correlations were observed between the initial mean dose of PSL and recurrence rate (r= 0.71; P= 0.013). Begg's funnel plot there was no evidence of publication bias in these studies (p=0.160). CONCLUSION: According to the results of this meta-analysis, 15 to 20 mg/day of prednisolone is the most effective dosage with the lowest recurrence rate in the treatment of subacute Granulomatous thyroiditis.

Item Type: Article
Creators:
CreatorsEmail
Soltani, A.UNSPECIFIED
Nourani, F.UNSPECIFIED
Roudsari, S. B.UNSPECIFIED
Jouybari, L.UNSPECIFIED
Fathi, M.UNSPECIFIED
Haghighat, S.UNSPECIFIED
Hadavi, M.UNSPECIFIED
Aletaha, A.UNSPECIFIED
Keywords: De Quervain Thyroiditis Glucocorticoids Meta-Analysis Prednisolone Recurrence Subacute Granulomatous Thyroiditis Subacute thyroiditis
Divisions:
Journal or Publication Title: Current reviews in clinical and experimental pharmacology
Journal Index: Pubmed
Identification Number: https://doi.org/10.2174/2772432816666211012092112
ISSN: 2772-4336 (Electronic) 2772-4328 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3768

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