Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Transcriptome analysis of biofilm formation under aerobic and microaerobic conditions in clinical isolates of Campylobacter spp

Fri Aug 19 02:44:44 2022

(2021) Transcriptome analysis of biofilm formation under aerobic and microaerobic conditions in clinical isolates of Campylobacter spp. Research in veterinary science. pp. 24-30. ISSN 1532-2661 (Electronic) 0034-5288 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/34847463

Abstract

It has been well documented that Campylobacter is the leading cause of foodborne infections and bacterial enteritis in high-income countries. The gastrointestinal tract of most warm-blooded animals, such as mammals and poultry, is prone to this pathogen. Infections caused by this bacterium in humans have usually been associated with the consumption of contaminated poultry meat. The important point about Campylobacter is that this bacterium has adapted to harsh environmental conditions along the food chain (poultry digestive tract to the consumer's plate) and developed an adapted mechanism to those conditions. This study aimed to compare the ability of Campylobacter jejuni and Campylobacter coli strains to form biofilms under aerobic and microaerobic conditions. The presence and expression of flab, FliS, DnaK, luxs, CsrA, Cj0688, and cosR genes involved in biofilm formation were investigated. Finally, the correlation between the biofilm forming ability of Campylobacter isolates and the presence/expression of selected genes has been explored. A significant correlation was observed between the presence and expression of some genes and the degree of biofilm formation in C. jejuni and C. coli isolates. A strong biofilm production was detected in strains harboring all selected genes with greater expression levels. The ability of C. jejuni and C. coli strains in biofilm formation is associated with the coordinated function and convergent expression of the selected genes. Seemingly, stress response- and motility-related genes have the most involvement in biofilm formation of C. jejuni and C. coli strains, while other genes have an accessory role in this phenomenon.

Item Type: Article
Creators:
CreatorsEmail
Ohadi, E.UNSPECIFIED
Bakhshi, B.UNSPECIFIED
Kalani, B. S.UNSPECIFIED
Talebi, M.UNSPECIFIED
Irajian, G.UNSPECIFIED
Keywords: Biofilm Campylobacter Gene expression
Divisions:
Page Range: pp. 24-30
Journal or Publication Title: Research in veterinary science
Journal Index: Pubmed
Volume: 142
Identification Number: https://doi.org/10.1016/j.rvsc.2021.11.009
ISSN: 1532-2661 (Electronic) 0034-5288 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3757

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