Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Clinical and diagnostic potential of regulatory T cell markers: From bench to bedside

Tue Aug 16 04:56:04 2022

(2021) Clinical and diagnostic potential of regulatory T cell markers: From bench to bedside. Transplant Immunology. p. 101518. ISSN 1878-5492 (Electronic) 0966-3274 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/34922022

Abstract

Regulatory T (Treg) cells are heterogeneous immune cell populations residing in the thymus and peripheral lymphatic tissues. This immune cell plays a central and critical role in maintaining immune tolerance against undesirable immune responses. Treg cells' phenotypic heterogeneity caused by different pathological conditions makes their identification and differentiation from non-suppressive T cells difficult. On the other hand, using nonspecific markers and variable isolation panels leads to undesirable outcomes. There are a variety of markers to identify functional Treg cells, including CD25, FOXP3, and CTLA-4, as well as the epigenetic signature of forkhead box P3 (FOXP3), which can be used for both natural and induced Treg cells. Phenotypic heterogeneity is a major concern in Treg purification when using nonspecific markers, which can be addressed by utilizing suitable isolation panels designed for different purposes. This review presents a clinical framework for Treg detection and isolation, focusing on Treg markers such as CD25, FOXP3, CTLA-4, CD127, GPA-33, and TSDR demethylation to design Treg isolation panels suitable for different Treg therapy purposes. The current review also highlights new reliable Treg markers applicable for different purposes.

Item Type: Article
Creators:
CreatorsEmail
Haddadi, M. H.UNSPECIFIED
Negahdari, B.UNSPECIFIED
Keywords: Ctla-4 Foxp3 Immuno-tolerance Regulator T cell Transplantation
Divisions:
Page Range: p. 101518
Journal or Publication Title: Transplant Immunology
Journal Index: Pubmed
Volume: 70
Identification Number: https://doi.org/10.1016/j.trim.2021.101518
ISSN: 1878-5492 (Electronic) 0966-3274 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3753

Actions (login required)

View Item View Item