Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Alarming and Threatening Signals from Health Centers About Multi Drug Resistance Staphylococcus haemolyticus

Wed Sep 28 13:19:15 2022

(2019) Alarming and Threatening Signals from Health Centers About Multi Drug Resistance Staphylococcus haemolyticus. Infectious disorders drug targets. pp. 118-127. ISSN 2212-3989 (Electronic) 1871-5265 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/30207248

Abstract

OBJECTIVES: Nowadays, due to the biofilm formation among coagulase-negative staphylococci (CoNS), acquisition of antibiotic resistance and virulence genes could be noted. These organisms resemble other staphylococcus that harbor mecA gene, which encode methicillin resistance but the diversity in CoNS is higher than other species. Based on increasing antibiotic resistance in Staphylococcus haemolyticus, analyzing of phenotypic and genotypic biofilm formation, antibiotic resistance and genes involved in this process, SCCmec and ACME typing were the aims of the current study. METHODS: 256 clinical CoNS isolates were collected that 49 isolates were identified as S. haemolyticus. For evaluation the antibiotic resistance patterns, disk agar diffusion method was applied, and also biofilm assay carried out among methicillin resistant S. haemolyticus and SCCmec and ACME typing. RESULTS: The results of antibiotic susceptibility indicated that the highest resistance was found for cotrimoxazole and erythromycin (86.6) and the frequency of blaA (96.5) and msrA (79.3) genes was much higher than others. Among MRSH isolates 58.6 showed a weak biofilm phenotype and 41.4 demonstrated a moderate biofilm density. Also, among the biofilm correlated genes, IS 256 (79.31) was the most frequent. The SCCmec typing of MRSH isolates indicated that the type V was dominant. CONCLUSION: Our findings indicated that the correlation between high rates of existence Is 256 gene and high prevalence of weak biofilm phenotype was among MRSH isolates. The current study revealed that multiple antibiotic resistance existed in S. haemolyticus isolates that is a warning for public health.

Item Type: Article
Creators:
CreatorsEmail
Maleki, A.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Taherikalani, M.UNSPECIFIED
Soroush, S.UNSPECIFIED
Keywords: Anti-Bacterial Agents/*pharmacology Biofilms Child DNA, Bacterial/genetics Drug Resistance, Multiple, Bacterial/*genetics Genotype Hospitalization *Hospitals, Pediatric Humans Iran/epidemiology Methicillin/pharmacology Microbial Sensitivity Tests Polymerase Chain Reaction Public Health Staphylococcal Infections/microbiology Staphylococcus haemolyticus/*drug effects/genetics/*isolation & purification CoNS Mrsh SCCmec typing Staphylococcus haemolyticus antibiotic resistance biofim.
Divisions:
Page Range: pp. 118-127
Journal or Publication Title: Infectious disorders drug targets
Journal Index: Pubmed
Volume: 19
Number: 2
Identification Number: https://doi.org/10.2174/1871526518666180911142806
ISSN: 2212-3989 (Electronic) 1871-5265 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3749

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