Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Mechanism of Action, Resistance, Synergism, and Clinical Implications of Delamanid Against Multidrug-Resistant Mycobacterium tuberculosis

Wed Nov 30 16:38:49 2022

(2021) Mechanism of Action, Resistance, Synergism, and Clinical Implications of Delamanid Against Multidrug-Resistant Mycobacterium tuberculosis. Frontiers in Microbiology. p. 13.

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Abstract

Multidrug-resistant (MDR) isolates of Mycobacterium tuberculosis (MTB) remain a primary global threat to the end of tuberculosis (TB) era. Delamanid (DLM) is a nitro-dihydro-imidazooxazole derivative utilized to treat MDR-TB. DLM has distinct mechanism of action, inhibiting methoxy- and keto-mycolic acid (MA) synthesis through the F420 coenzyme mycobacteria system and generating nitrous oxide. While DLM resistance among MTB strains is uncommon, there are increasing reports in Asia and Europe, and such resistance will prolong the treatment courses of patients infected with MDR-TB. In this review, we address the antimycobacterial properties of DLM, report the global prevalence of DLM resistance, discuss the synergism of DLM with other anti-TB drugs, and evaluate the documented clinical trials to provide new insights into the clinical use of this antibiotic.</p>

Item Type: Article
Creators:
CreatorsEmail
Khoshnood, S.UNSPECIFIED
Taki, E.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Kaviar, V. H.UNSPECIFIED
Haddadi, M. H.UNSPECIFIED
Farshadzadeh, Z.UNSPECIFIED
Kouhsari, E.UNSPECIFIED
Goudarzi, M.UNSPECIFIED
Heidary, M.UNSPECIFIED
Keywords: Mycobacterium tuberculosis tuberculosis delamanid review TB additional drug-resistance antituberculosis drugs bactericidal activity bedaquiline opc-67683 therapy tb compassionate adolescents prevalence Microbiology
Divisions:
Page Range: p. 13
Journal or Publication Title: Frontiers in Microbiology
Journal Index: ISI
Volume: 12
Identification Number: https://doi.org/10.3389/fmicb.2021.717045
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3744

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