Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients

Fri Aug 19 03:49:03 2022

(2021) The association between interferon lambda 3 and 4 gene single-nucleotide polymorphisms and the recovery of COVID-19 patients. Virology Journal. p. 7.

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Background The recent pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has elevated several clinical and scientific questions. These include how host genetic factors influence the pathogenesis and disease susceptibility. Therefore, the aim of this study was to evaluate the impact of interferon lambda 3 and 4 (IFNL3/4) gene polymorphisms and clinical parameters on the resistance and susceptibility to coronavirus disease 2019 (COVID-19) infection. Methods A total of 750 SARS-CoV-2 positive patients (375 survivors and 375 nonsurvivors) were included in this study. All single-nucleotide polymorphisms (SNPs) on IFNL3 (rs12979860, rs8099917, and rs12980275) and IFNL4 rs368234815 were genotyped by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results In this study, a higher viral load (low PCR Ct value) was shown in nonsurvivor patients. In survivor patients, the frequency of the favorable genotypes of IFNL3/4 SNPs (rs12979860 CC, rs12980275 AA, rs8099917 TT, and rs368234815 TT/TT) was significantly higher than in nonsurvivor patients. Multivariate logistic regression analysis has shown that a higher low-density lipoprotein (LDL), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and PCR Ct value, and lower 25-hydroxyvitamin D, and also IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 rs368234815 increment G/ increment G genotypes were associated with the severity of COVID-19 infection. Conclusions The results of this study proved that the severity of COVID-19 infection was associated with clinical parameters and unfavorable genotypes of IFNL3/IFNL4 SNPs. Further studies in different parts of the world are needed to show the relationship between severity of COVID-19 infection and host genetic factors.

Item Type: Article
Creators:
CreatorsEmail
Rahimi, P.UNSPECIFIED
Tarharoudi, R.UNSPECIFIED
Rahimpour, A.UNSPECIFIED
Amroabadi, J. M.UNSPECIFIED
Ahmadi, I.UNSPECIFIED
Anvari, E.UNSPECIFIED
Siadat, S. D.UNSPECIFIED
Aghasadeghi, M.UNSPECIFIED
Fateh, A.UNSPECIFIED
Keywords: SARS-CoV-2 COVID-19 Interferon lambda 3 Interferon lambda 4 Single-nucleotide polymorphisms treatment responses vitamin-d il28b ifnl4 Virology
Divisions:
Page Range: p. 7
Journal or Publication Title: Virology Journal
Journal Index: ISI
Volume: 18
Number: 1
Identification Number: https://doi.org/10.1186/s12985-021-01692-z
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3743

Actions (login required)

View Item View Item