Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association between Blastocystis sp. infection and immunocompromised patients: a systematic review and meta-analysis

Fri Aug 19 03:51:24 2022

(2021) Association between Blastocystis sp. infection and immunocompromised patients: a systematic review and meta-analysis. Environmental Science and Pollution Research. pp. 60308-60328. ISSN 0944-1344

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Abstract

The significance of opportunistic infections in immunocompromised patients and the enigmatic pathogenicity of Blastocystis directed us to conduct the first global systematic review and meta-analysis on Blastocystis prevalence, odds ratios (ORs), and subtypes distribution in various immunocompromised patients (HIV/AIDS, cancer and hemodialysis patients, as well as transplant recipients). The systematic searching procedure was done in Web of Science, PubMed, Scopus, and Google Scholar databases for relevant published literature until November 11, 2020. Random-effects model was utilized to calculate the weighted estimates and 95 confidence intervals (95 CIs). The computed pooled prevalence of Blastocystis inferred from 118 papers (128 datasets) on immunocompromised patients was 10.3 (95 CI: 8.7-12.2), with 16.1 (95 CI: 11.3-22.2), 12.5 (95 CI: 8.5-18), 8.4 (95 CI: 6.6-10.6), and 6 (95 CI: 2.6-13.3) for hemodialysis patients, cancer patients, HIV/AIDS patients, and transplant recipients, respectively. Based on 50 case-control studies (54 datasets), the highest ORs were associated with cancer 2.81 (95% CI: 1.24-6.38, P = 0.013) and hemodialysis patients 2.78 (95% CI: 1.19-6.48, P = 0.018). The most frequent subtype being found in immunocompromised patients was ST3 41.7% (95% CI: 31.4-52.7%), followed by ST1 31.7% (95% CI: 23.2-41.8%) and ST2 23.1% (95% CI: 14.8-34.1%). Also, the weighted frequency of Blastocystis in various subgroups (publication year, WHO regions, geographical distribution, continents, and country income) was analyzed separately. In total, the results of the present meta-analysis highlighted that one's immunodeficiency status is probably associated with an increased Blastocystis infection, underpinning strict preventive measures to be taken.

Item Type: Article
Creators:
CreatorsEmail
Asghari, A.UNSPECIFIED
Sadeghipour, Z.UNSPECIFIED
Hassanipour, S.UNSPECIFIED
Abbasali, Z.UNSPECIFIED
Ebrahimzadeh-Parikhani, H.UNSPECIFIED
Hashemzaei, M.UNSPECIFIED
Alimardani, V.UNSPECIFIED
Hatam, G.UNSPECIFIED
Keywords: Blastocystis sp Prevalence Subtypes Immunocompromised patients HIV AIDS patients Cancer patients Transplant recipients Hemodialysis patients Systematic review Meta-analysis intestinal parasitic infections human-immunodeficiency-virus hiv-positive individuals hiv/aids patients clinical-significance molecular characterization opportunistic infections equatorial-guinea hominis infection enteric protozoa Environmental Sciences & Ecology
Divisions:
Page Range: pp. 60308-60328
Journal or Publication Title: Environmental Science and Pollution Research
Journal Index: ISI
Volume: 28
Number: 43
Identification Number: https://doi.org/10.1007/s11356-021-16187-1
ISSN: 0944-1344
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3741

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