Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

THE ASSOCIATION BETWEEN METABOLIC SYNDROME AND EROSIVE ESOPHAGITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Tue Aug 16 04:38:58 2022

(2021) THE ASSOCIATION BETWEEN METABOLIC SYNDROME AND EROSIVE ESOPHAGITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS. Excli Journal. pp. 1532-1543. ISSN 1611-2156

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Abstract

Although several studies have shown that each of the metabolic syndrome (MetS) components can be a risk factor for erosive esophagitis (EE), the association between MetS and EE is still a challenging subject, as studies about this association have shown inconsistent results. Therefore, this study was conducted to evaluate the association between MetS and EE. In this study, we followed the MOOSE protocol and the PRISMA guidelines for reporting the results. Web of Science (ISI), Cochrane Library (Cochrane Database of Systematic Reviews CDSR), EM-BASE, Scopus, Science Direct, PubMed/Medline, EBSCO, CINAHL, and Google Scholar search engine were searched for articles published until January 2021. Heterogeneity between studies was estimated by I2 index and Q test. All analyses were performed using Comprehensive Meta-Analysis Software. Finally, 12 studies entered the meta-analysis process after qualitative assessment. MetS was significantly associated with increased risk of EE (OR=1.488 95 % CI: 1.352-1.638, P<0.001; Heterogeneity: I2=55.57, P<0.001) in 12 studies with a sample size of 45285 (12825 cases and 29377 controls). In subgroup analysis based on types of studies (P=0.832), MetS diagnostic criteria (P=0.083) and quality of studies (P=0.612), no significant association was found. Sensitivity analysis showed that the overall estimation of effect size is still robust after omission of individual studies from the meta-analysis. Publication bias based on the Begg's test (P=0.945) and Egger's test (P=0.753) were not significant. MetS increases the risk of EE compared to control groups. Future studies should examine if MetS treatment reduces the risk of EE.

Item Type: Article
Creators:
CreatorsEmail
Azami, M.UNSPECIFIED
Salamati, M.UNSPECIFIED
Ranjbar, R.UNSPECIFIED
Sahebkar, A.UNSPECIFIED
Keywords: Metabolic syndrome erosive esophagitis meta-analysis gastroesophageal-reflux disease risk-factors central adiposity liver-function hepatitis-b prevalence obesity management asia Life Sciences & Biomedicine - Other Topics
Divisions:
Page Range: pp. 1532-1543
Journal or Publication Title: Excli Journal
Journal Index: ISI
Volume: 20
Identification Number: https://doi.org/10.17179/excli2021-4282
ISSN: 1611-2156
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3737

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