Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Dimethyl fumarate: Regulatory effects on the immune system in the treatment of multiple sclerosis

Mon Jul 15 23:20:51 2024

(2019) Dimethyl fumarate: Regulatory effects on the immune system in the treatment of multiple sclerosis. Journal of Cellular Physiology. pp. 9943-9955. ISSN 0021-9541

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Dimethyl fumarate (DMF) is an important oral treatment option for various autoimmune diseases, such as multiple sclerosis (MS) and psoriasis. DMF and its dynamic metabolite, monomethyl fumarate (MMF) are the major compounds that exert therapeutic effects on several pathologic conditions in part, through downregulation of immune responses. The exact mechanism of DMF is yet to be fully understood even though its beneficial effects on the immune system are extensively studied. It has been shown that DMF/MMF can affect various immune cells, which can get involved in both the naive and adaptive immune systems, such as T cells, B cells, dendritic cells, macrophages, neutrophils, and natural killer cells. It is suggested that DMF/MMF may exert their effect on immune cells through inhibition of nuclear factor-B translocation, upregulation of nuclear factor erythroid-derived 2(E2)-related factor antioxidant pathway, and activation of hydroxyl carboxylic acid receptor 2. In this review, the mechanisms underlying the modulatory functions of DMF or MMF on the main immune cell populations involved in the immunopathogenesis of MS are discussed.

Item Type: Article
Hojjat-Farsangi, M.UNSPECIFIED
Ghalamfarsa, G.UNSPECIFIED
Jadidi-Niaragh, F.UNSPECIFIED
Keywords: dimethyl fumarate immune system multiple sclerosis treatment natural-killer-cells nf-kappa-b neutrophil extracellular traps placebo-controlled phase-3 quality-of-life t-cell acid esters cytokine production parkinsons-disease clinical-efficacy Cell Biology Physiology
Page Range: pp. 9943-9955
Journal or Publication Title: Journal of Cellular Physiology
Journal Index: ISI
Volume: 234
Number: 7
Identification Number:
ISSN: 0021-9541
Depositing User: مهندس مهدی شریفی

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