Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Global prevalence and associated risk factors of diarrheagenic Giardia duodenalis in HIV/AIDS patients: A systematic review and meta-analysis

Fri Aug 19 04:36:55 2022

(2021) Global prevalence and associated risk factors of diarrheagenic Giardia duodenalis in HIV/AIDS patients: A systematic review and meta-analysis. Microbial Pathogenesis. p. 16. ISSN 0882-4010

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Abstract

Giardia duodenalis is one of the leading causes of diarrhea, mostly in underdeveloped nations of Africa and Asia. The present review provides insights into the prevalence, odds ratios (ORs) and associated risk factors of giardiasis in HIV/AIDS patients. Four major English databases (Web of Science, PubMed, Scopus, and Google Scholar) were excavated for relevant literature without time limitation until 20 November 2020. Next, meta analysis was performed using a random-effects model and 95 confidence intervals (CIs). As well, heterogeneity among studies was evaluated using Cochran's Q and the I-2-statistic. Totally, 19,218 HIV/AIDS patients in 130 studies were examined, showing a 5 (95 CI: 4.2-6) pooled prevalence. Also, the weighted random effects OR of G. duodenalis infection among HIV/AIDS patients in comparison with their controls in 48 case control studies was estimated as 1.71 (95 CI: 1.1-2.66, p = 0.016). Based on sensitivity analysis, there was no remarkable variation in the pooled OR upon omitting individual studies. Diarrhea was a potent risk factor, since HIV/AIDS patients with diarrhea were 3.8-times (95 CI: 1.6-8.9, p = 0.002) more prone to G. duodenalis infection than those without diarrhea. Moreover, the prevalence of the parasitic infection was 1.2-times higher in patients without antiretroviral therapy (ART) than those with ART (p = 0.312). Meta-regression was employed to evaluate the possible association between G. duodenalis frequency in HIV/AIDS patients and some variables such as sample size, publication year, and HDI. Additionally, the pooled prevalence of G. duodenalis infection was estimated based on several subgroups, including publication years, WHO regions, countries, continents, country incomes, and CD4(+) T-cell levels. Altogether, the epidemiology of giardiasis in HIV/AIDS patients and its association with various risk factors is still open to question and requires more detailed and comprehensive investigations.

Item Type: Article
Creators:
CreatorsEmail
Mahdavi, F.UNSPECIFIED
Shams, M.UNSPECIFIED
Sadrebazzaz, A.UNSPECIFIED
Shamsi, L.UNSPECIFIED
Omidian, M.UNSPECIFIED
Asghari, A.UNSPECIFIED
Hassanipour, S.UNSPECIFIED
Salemi, A. M.UNSPECIFIED
Keywords: Giardia duodenalis Giardiasis HIV AIDS Prevalence Review intestinal parasitic infections quality-of-life antiretroviral therapy southern ethiopia opportunistic infections enteric pathogens hiv-infection aids patients cell counts bahir dar Immunology Microbiology
Divisions:
Page Range: p. 16
Journal or Publication Title: Microbial Pathogenesis
Journal Index: ISI
Volume: 160
Identification Number: https://doi.org/10.1016/j.micpath.2021.105202
ISSN: 0882-4010
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3728

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