Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis

Sat May 25 20:17:56 2024

(2021) Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis. Open Medicine. pp. 70-86. ISSN 2391-5463

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Gestational diabetes mellitus (GDM) can have adverse effects on pregnancy. GDM is associated with changes in the lipid profile of pregnant women. Finding out the early ways to diagnose GDM can prevent the adverse outcomes. This meta-analysis study aimed to determine the effect of GDM on lipid profile. PubMed, ProQuest, Web of Science, Scopus, Science Direct, Google Scholar, and ClinicalTrial were systematically searched for published articles relating to GDM until 2021 according to PRISMA guidelines. Newcastle Ottawa scale was used to assess the quality of the studies. Thirty-three studies with a sample size of 23,792 met the criteria for entering the meta-analysis. Pooled standardized mean difference (SMD) for total cholesterol (TC) and triglyceride (TG) was 0.23 mg/dL (95 CI: 0.11-0.34) and 1.14 mg/dL (95 CI: 0.91-1.38), respectively. The mean of TC and TG in people with GDM was higher than that in normal pregnant women. A similar pattern was observed for the very low-density lipoprotein (VLDL) and TG/high-density lipoprotein (HDL) ratio, with pooled SMD of 0.99 mg (95 CI: 0.71-1.27) and 0.65 mg (95 CI: 0.36-0.94), respectively. Pooled SMD for HDL was -0.35 mg/dL (95 CI: -0.54 to -0.16), women with GDM had a mean HDL lower than normal pregnant women. Although pooled SMD was higher for low-density lipoprotein (LDL) in the GDM group, this difference was not significant (0.14 95% CI: -0.04 to 0.32). Of all the lipid profiles, the largest difference between the GDM and control groups was observed in TG (SMD: 1.14). Elevated serum TG had the strongest effect on GDM. Higher levels of TC, LDL, VLDL, and TG/HDL ratio, and lower level of HDL were exhibited in GDM group. So, these markers can be considered as a reliable marker in the diagnosis of GDM.

Item Type: Article
Keywords: gestational diabetes mellitus lipid profile triglyceride TG HDL ratio total cholesterol LDL-C HDL-C VLDL-C insulin-resistance cholesterol ratio pregnancy women risk hyperlipidemia triglyceride associations delivery density General & Internal Medicine
Page Range: pp. 70-86
Journal or Publication Title: Open Medicine
Journal Index: ISI
Volume: 17
Number: 1
Identification Number:
ISSN: 2391-5463
Depositing User: مهندس مهدی شریفی

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