Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A systematic review and meta-analysis of serum resistin level and its relation to HOMA-IR score using meta-regression in nonalcoholic fatty liver disease patients

Fri Jul 1 21:57:33 2022

(2021) A systematic review and meta-analysis of serum resistin level and its relation to HOMA-IR score using meta-regression in nonalcoholic fatty liver disease patients. Mediterranean Journal of Nutrition and Metabolism. pp. 219-231. ISSN 1973-798X

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Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) comorbidity with adipose tissue dysfunction is not new and studies have focused on how adipose tissue influences NAFLD pathophysiology. OBJECTIVE: Quantification of nature and magnitude of the association between serum resistin and also insulin resistance, by calculating pooled Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) score, with NAFLD pathophysiology was the objective of the current study. METHODS: Using systematic reviewand meta-analysis and standardized mean difference (SMD) as the effect size, the levels of resistin and HOMA-IR scores have been investigated in NAFLD subjects in comparison with controls in the case-control studies using random-effects models. RESULTS: This meta-analysis retrieved a total number of 665 and 522 cases and 671 and 555 control subjects until May 2020 for serum levels of resistin and HOMA-IR score until May 2020. The final analyses demonstrated that pooled SMD of resistin and HOMA-IR score was 0.687 (95 confidence interval, 0.070-1.304) and 1.368 (95 confidence interval, 1.080-1.655); respectively. Moreover, the p-value for the test of significance for each pooled SMD was examined by the z-test and calculated as 0.029 and 0.000 for resistin and HOMA-IR score (clearly considered as statistically significant). . CONCLUSION: Based on the findings, the HOMA-IR score and the serum levels of resistin in NAFLD subjects are associated with disease pathogenesis.

Item Type: Article
Creators:
CreatorsEmail
Mirzaei, A.UNSPECIFIED
Asal, A.UNSPECIFIED
Seidkhani-Nahal, A.UNSPECIFIED
Noori-Zadeh, A.UNSPECIFIED
Keywords: Resistin HOMA-IR NAFLD NASH simple steatosis insulin-resistance adipokines pathogenesis adiponectin cytokines severity General & Internal Medicine Nutrition & Dietetics
Divisions:
Page Range: pp. 219-231
Journal or Publication Title: Mediterranean Journal of Nutrition and Metabolism
Journal Index: ISI
Volume: 14
Number: 3
Identification Number: https://doi.org/10.3233/mnm-210538
ISSN: 1973-798X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3660

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