Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of IL-15 and IP-10 Serum Levels with Cytomegalovirus Infection, CMV Viral Load and Cyclosporine Level after Kidney Transplantation

Sun Nov 27 21:18:18 2022

(2021) Association of IL-15 and IP-10 Serum Levels with Cytomegalovirus Infection, CMV Viral Load and Cyclosporine Level after Kidney Transplantation. Reports of Biochemistry and Molecular Biology. pp. 217-224. ISSN 23223480 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Cytomegalovirus (CMV) infection is the most common complications following kidney transplantation. Natural killer (NK) cells demonstrated critical anti-viral role in controlling and elimination of CMV after transplantation. Interleukin-15 (IL-15) is a pleiotropic cytokine that promotes the activity of NK cells and strengthens the acquired immune system. Also, IP10 (CXCL10) is a chemotactic factor which regulates NK cell recruitment and antiviral immune response. We aimed to determine the correlation between the serum levels of IL-15 and IP-10 cytokines with CMV infection, CMV viral load, and cyclosporine as a major immunosuppressive treatment after transplantation. Methods: Fifty-eight kidney transplant recipient patients without evidence of CMV virus disease before transplantation surgery were included in the study. From the day of transplant surgery, the patients were evaluated based on the presence of CMV Ag pp65, CMV viral load, serum levels of IL-15 & IP-10, Cyclosporine levels (C0 & C2), Glomerular Filtration Rate (GFR), and hematological & biochemical Index, up to 75 days. Results: Comparison analysis of serum levels of IL-15 and IP-10 showed no significant association with CMV infection in kidney transplant recipients. In addition, CMV viral load and cyclosporine levels at C0 and C2 did not affect patients' IL-15 and IP-10 levels. Conclusions: The levels of IP-10 and IL-15 cytokines are not affected with CMV infection, even if a viral infection occurs in the early days after transplantation or long afterwards. In addition, taking the different levels of cyclosporine did not affect the cytokines levels. Other mechanisms may play a role in maintaining the levels of these cytokines. © 2021, Reports of Biochemistry and Molecular Biology. All Rights Reserved.

Item Type: Article
Creators:
CreatorsEmail
Asadzadeh, R.UNSPECIFIED
Ahmadpoor, P.UNSPECIFIED
Nafar, M.UNSPECIFIED
Samavat, S.UNSPECIFIED
Nikoueinejad, H.UNSPECIFIED
Hosseinzadeh, M.UNSPECIFIED
Mamizadeh, N.UNSPECIFIED
Hatami, S.UNSPECIFIED
Masoumi, E.UNSPECIFIED
Amirzargar, A.UNSPECIFIED
Keywords: Cytokine Cytomegalovirus Interleukin-15 IP-10 Transplantation
Divisions:
Page Range: pp. 217-224
Journal or Publication Title: Reports of Biochemistry and Molecular Biology
Journal Index: Scopus
Volume: 10
Number: 2
ISSN: 23223480 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3640

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