Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The effect of dapsone in testosterone enanthate-induced polycystic ovary syndrome in rat

Sun Nov 27 23:28:19 2022

(2021) The effect of dapsone in testosterone enanthate-induced polycystic ovary syndrome in rat. The Journal of steroid biochemistry and molecular biology. p. 105977. ISSN 1879-1220 (Electronic) 0960-0760 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/34428594

Abstract

BACKGROUND: One of the most common reasons for infertility is polycystic ovary syndrome (PCOS). PCOS is related to metabolic syndrome, weight gain, type 2 diabetes mellitus, and cardiovascular diseases. Some of the causes of PCOS are dysfunction in the hypothalamus-pituitary-ovarian axis, insulin activity as well as over-activity of sympathetic nerves and elevation in serum levels of pro-inflammatory cytokines. Dapsone, a sulfonamide antibacterial agent, has anti-inflammatory effects such as decreasing inflammatory cytokine levels like TNF-alpha and IL-1beta. METHODS: PCOS was induced by subcutaneous injection of testosterone enanthate (1 mg/100 g) in 21 days old female rats for 35 days. Then, the MET control received metformin (300 mg/kg/day, orally) for 28 days, and to evaluate the efficacy of dapsone (DAP), the DAP group received (12.5 mg/kg, orally) for 28 days. Then, on the last day of the study, the rats were euthanized and the blood was collected to measure the serum levels of hormones, glucose, LDL, LDL/HDL and the left ovaries were dissected for histopathological assay. RESULTS: In the PCOS group, the serum levels of glucose, LDL and LDL/HDL were significantly higher than in the control group (P < 0.001). In addition, the levels of LH, FSH and testosterone changed in the PCOS group compared to the control (P < 0.001). The histopathological morphology changes of the ovary of the PCOS group were significant. Treatment with dapsone and metformin reversed the effects of testosterone in the DAP and MET groups. CONCLUSIONS: Based on the data, dapsone displayed a good antiandrogenic role via decreasing the testosterone levels in PCOS-induced rats.

Item Type: Article
Creators:
CreatorsEmail
Shirooie, S.UNSPECIFIED
Khaledi, E.UNSPECIFIED
Dehpour, A. R.UNSPECIFIED
Noori, T.UNSPECIFIED
Khazaei, M.UNSPECIFIED
Sadeghi, F.UNSPECIFIED
Sobarzo-Sanchez, E.UNSPECIFIED
Keywords: Dapsone Polycystic Progesterone Rat Testosterone
Divisions:
Page Range: p. 105977
Journal or Publication Title: The Journal of steroid biochemistry and molecular biology
Journal Index: Pubmed
Volume: 214
Identification Number: https://doi.org/10.1016/j.jsbmb.2021.105977
ISSN: 1879-1220 (Electronic) 0960-0760 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3626

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