Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Ascorbic Acid to Prevent Postpolypectomy Bleeding in the Colon: A Randomized Controlled Trial

Tue Aug 16 12:41:10 2022

(2021) Ascorbic Acid to Prevent Postpolypectomy Bleeding in the Colon: A Randomized Controlled Trial. Asian journal of endoscopic surgery. ISSN 1758-5910 (Electronic) 1758-5902 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/34448547

Abstract

INTRODUCTION: It has been reported that vitamin C replacement can quickly reverse nonspecific bleeding in surgical patients with normal coagulation parameters. We evaluated the effect of intravenous ascorbic acid administration for prevention of postpolypectomy bleeding in large polyps of the colon. MATERIALS AND METHODS: Patients with large polyps with heads larger than 10 mm, stalk diameter larger than 5 mm, and a length larger than 10 mm were included in this randomized controlled clinical trial. In the study group, the first 500 mg intravenous dose of vitamin C diluted in normal saline was administered 2 h before colonoscopic resection of polyps and the second and third similar doses were administered on days 2 and 3 of polypectomy, respectively. The control group received normal saline in a similar fashion. The resection of polyps was performed in snare and cut-blend mode. Early and late postoperative bleeding were compared between the two groups. RESULTS: A total of 153 polyps were resected by endoscopic polypectomy. Early bleeding was observed in 7.2 of the patients, which was significantly lower in the vitamin C group (2.6 vs 11.8, P = 0.03). Late bleeding was observed in 6.5 of the patients with a trend lower in the vitamin C group (2.6 vs 10.5, P = 0.057). The proportion of postprocedural bleeding was significantly higher in the vitamin C group (5 vs 20, P = 0.007). Hazard ratios of early and postprocedural bleeding were 78 and 76 lower in the vitamin C group compared to the control group (P < 0.05). CONCLUSION: Intravenous ascorbic acid infusion could reduce postpolypectomy bleeding.

Item Type: Article
Creators:
CreatorsEmail
Vahdat Shariatpanahi, Z.UNSPECIFIED
Shahbazi, S.UNSPECIFIED
Shahbazi, E.UNSPECIFIED
Keywords: coagulation hematochezia polyp
Divisions:
Journal or Publication Title: Asian journal of endoscopic surgery
Journal Index: Pubmed
Identification Number: https://doi.org/10.1111/ases.12977
ISSN: 1758-5910 (Electronic) 1758-5902 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3624

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