Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The effect of vitamin D supplementation on flow-mediated dilatation, oxidized LDL and intracellular adhesion molecule 1 on type 2 diabetic patients with hypertension: A randomized, placebo-controlled, double-blind trial

Wed Aug 10 12:52:08 2022

(2021) The effect of vitamin D supplementation on flow-mediated dilatation, oxidized LDL and intracellular adhesion molecule 1 on type 2 diabetic patients with hypertension: A randomized, placebo-controlled, double-blind trial. Diabetes & Metabolic Syndrome-Clinical Research & Reviews. p. 7. ISSN 1871-4021

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Abstract

Aims: Current study aimed to evaluate the effect of vitamin D supplementation on flow-mediated dilatation (FMD), oxidized LDL (oxLDL) and intracellular adhesion molecule 1 (ICAM1) in type 2 diabetic patients with hypertension. Methods: In a double-blinded, placebo-controlled trial, 44 patients were randomly divided into vitamin D group (2000 IU/d, n = 23) and placebo group (control, n = 21) for 12 weeks. Vascular function with FMD, Serum 25-OH vitamin D, oxLDL and ICAM1 were assessed at the baseline and after the intervention. Results: In intervention group serum level of vitamin D increased from 32.42 +/- 10.56 to 40.45 +/- 12.94 (p < 0.001). In the vitamin D group, oxLDL and ICAM1 significantly decreased and FMD increased significantly in both groups (p < 0.001). The level of oxLDL (p = 0.017) and ICAM1 (p < 0.001) were significantly lower in the vitamin D group than the placebo group and FMD (p < 0.001) was significantly higher in the vitamin D group. Conclusions: Vitamin D supplementation of 2000 IU/d for 12 weeks can improve endothelial function and decrease ICAM1 and oxLDL in type 2 diabetic patients with hypertension. (C) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Qasemi, R.UNSPECIFIED
Ghavamzadeh, S.UNSPECIFIED
Faghfouri, A. H.UNSPECIFIED
Valizadeh, N.UNSPECIFIED
Mohammadi, A.UNSPECIFIED
Sayyadi, H.UNSPECIFIED
Keywords: Diabetes mellitus Vitamin D Hypertension Flow-mediated dilatation Oxidized LDL Intracellular adhesion molecule 1 improves endothelial function oxidative stress cardiovascular-disease insulin-resistance african-american nadph oxidase mellitus glucose dysfunction prevention Endocrinology & Metabolism
Divisions:
Page Range: p. 7
Journal or Publication Title: Diabetes & Metabolic Syndrome-Clinical Research & Reviews
Journal Index: ISI
Volume: 15
Number: 4
Identification Number: https://doi.org/10.1016/j.dsx.2021.102200
ISSN: 1871-4021
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3598

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