Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Immunoinformatic Analysis of Calcium-Dependent Protein Kinase 7 (CDPK7) Showed Potential Targets for Toxoplasma gondii Vaccine

Thu Aug 18 12:31:27 2022

(2021) Immunoinformatic Analysis of Calcium-Dependent Protein Kinase 7 (CDPK7) Showed Potential Targets for Toxoplasma gondii Vaccine. Journal of Parasitology Research. p. 20. ISSN 2090-0023

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Apicomplexan parasites, including Toxoplasma gondii (T. gondii), express different types of calcium-dependent protein kinases (CDPKs), which perform a variety of functions, including attacking and exiting the host cells. In the current bioinformatics study, we have used several web servers to predict the basic features and specifications of the CDPK7 protein. The findings showed that CDPK7 protein has 2133 amino acid residues with an average molecular weight (MW) of 219085.79 D. The aliphatic index with 68.78 and grand average of hydropathicity (GRAVY) with -0.331 score were estimated. The outcomes of current research showed that the CDPK7 protein included 502 alpha-helix, 1311 random coils, and 320 extended strands with GOR4 method. Considering the Ramachandran plot, the favored region contains more than 92 of the amino acid residues. In addition, evaluation of antigenicity and allergenicity showed that CDPK7 protein has immunogenic and nonallergenic nature. The present research provides key data for more animal-model study on the CDPK7 protein to design an efficient vaccine against toxoplasmosis in the future.

Item Type: Article
Creators:
CreatorsEmail
Taghipour, A.UNSPECIFIED
Tavakoli, S.UNSPECIFIED
Sabaghan, M.UNSPECIFIED
Foroutan, M.UNSPECIFIED
Majidiani, H.UNSPECIFIED
Soltani, S.UNSPECIFIED
Badri, M.UNSPECIFIED
Ghaffari, A. D.UNSPECIFIED
Soltani, S.UNSPECIFIED
Keywords: b-cell epitopes bioinformatics analysis secondary-structure promising targets prediction parasite candidate antigens history Parasitology
Divisions:
Page Range: p. 20
Journal or Publication Title: Journal of Parasitology Research
Journal Index: ISI
Volume: 2021
Identification Number: https://doi.org/10.1155/2021/9974509
ISSN: 2090-0023
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3594

Actions (login required)

View Item View Item