Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effect of prone position on respiratory parameters, intubation and death rate in COVID-19 patients: systematic review and meta-analysis

Fri Aug 19 03:49:58 2022

(2021) Effect of prone position on respiratory parameters, intubation and death rate in COVID-19 patients: systematic review and meta-analysis. Scientific Reports. p. 16. ISSN 2045-2322

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Abstract

Prone position (PP) is known to improve oxygenation and reduce mortality in COVID-19 patients. This systematic review and meta-analysis aimed to determine the effects of PP on respiratory parameters and outcomes. PubMed, EMBASE, ProQuest, SCOPUS, Web of Sciences, Cochrane library, and Google Scholar were searched up to 1st January 2021. Twenty-eight studies were included. The Cochran's Q-test and I-2 statistic were assessed heterogeneity, the random-effects model was estimated the pooled mean difference (PMD), and a meta-regression method has utilized the factors affecting heterogeneity between studies. PMD with 95 confidence interval (CI) of PaO2/FIO2 Ratio in before-after design, quasi-experimental design and in overall was 55.74, 56.38, and 56.20 mmHg. These values for Spo(2) (Sao(2)) were 3.38, 17.03, and 7.58. PP in COVID-19 patients lead to significantly decrease of the Paco(2) (PMD: -8.69; 95 CI -14.69 to -2.69 mmHg) but significantly increase the PaO2 (PMD: 37.74; 95 CI 7.16-68.33 mmHg). PP has no significant effect on the respiratory rate. Based on meta-regression, the study design has a significant effect on the heterogeneity of Spo(2) (Sao(2)) (Coefficient: 12.80; p<0.001). No significant associations were observed for other respiratory parameters with sample size and study design. The pooled estimate for death rate and intubation rates were 19.03 (8.19-32.61) and 30.68 (21.39-40.75). The prone positioning was associated with improved oxygenation parameters and reduced mortality and intubation rate in COVID-19 related respiratory failure.

Item Type: Article
Creators:
CreatorsEmail
Aeen, F. B.UNSPECIFIED
Pakzad, R.UNSPECIFIED
Rad, M. G.UNSPECIFIED
Abdi, F.UNSPECIFIED
Zaheri, F.UNSPECIFIED
Mirzadeh, N.UNSPECIFIED
Keywords: ards failure Science & Technology - Other Topics
Divisions:
Page Range: p. 16
Journal or Publication Title: Scientific Reports
Journal Index: ISI
Volume: 11
Number: 1
Identification Number: https://doi.org/10.1038/s41598-021-93739-y
ISSN: 2045-2322
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3592

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