Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Parasite-derived microRNAs as a diagnostic biomarker: potential roles, characteristics, and limitations

Thu Aug 18 13:03:46 2022

(2021) Parasite-derived microRNAs as a diagnostic biomarker: potential roles, characteristics, and limitations. Journal of Parasitic Diseases. ISSN 09717196 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

MicroRNAs (miRNAs), a subclass of small regulatory RNAs that present from ancient unicellular protozoans to parasitic helminths and parasitic arthropods. MiRNAs' mode of action has attracted wide attention as a result of their unique functional importance. MiRNAs play a role in diverse physiological and pathological processes ranging from organ development, immune function to apoptosis and cancer at the post-transcription gene expression. Thus, miRNAs are known to be targets for clinical treatment and therapy. The discovery of the high stability of circulating miRNA in various types of host body fluids, such as whole blood, serum, plasma, saliva, and urine has increased great interest among researchers in the potential of circulating miRNA as a prognosis/diagnosis of infectious. Some circulating miRNAs biomarkers advanced to clinical applications related to human diseases. However, this idea starts to come only in the fields of infectious disease. The goal of this review is to enhance the current understanding of these molecules and their applicability in the field of medicine. A detailed review of the available literature consulting tools performed in online repositories such as NCBI, PubMed, Medline, ScienceDirect, and UpToDate. This review summarizes an overview of preclinical studies using circulating miRNAs biomarkers against infectious diseases affecting humans. The use of miRNA as a safe and potential tool is encouraging news, considering that until now, guidelines for the use of miRNA in clinical practice are still lacking. © 2021, Indian Society for Parasitology.

Item Type: Article
Creators:
CreatorsEmail
Raissi, V.UNSPECIFIED
Zibaei, M.UNSPECIFIED
Raiesi, O.UNSPECIFIED
Samani, Z.UNSPECIFIED
Yarahmadi, M.UNSPECIFIED
Etemadi, S.UNSPECIFIED
Istiqomah, A.UNSPECIFIED
Alizadeh, Z.UNSPECIFIED
Shadabi, S.UNSPECIFIED
Sohrabi, N.UNSPECIFIED
Ibrahim, A.UNSPECIFIED
Keywords: Characteristics Diagnostic biomarker Limitations MicroRNAs Parasitic infection
Divisions:
Journal or Publication Title: Journal of Parasitic Diseases
Journal Index: Scopus
Identification Number: https://doi.org/10.1007/s12639-021-01395-w
ISSN: 09717196 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3500

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