Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The association of diabetes mellitus and gender with risk of bone fractures: A systematic review and meta-analysis

Tue Jul 23 21:51:07 2024

(2017) The association of diabetes mellitus and gender with risk of bone fractures: A systematic review and meta-analysis. Biomedical Research-India. pp. 7793-7799. ISSN 0970-938X

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Bone fracture shows a growing trend. This increase is a result of several factors occurs. In this study, a meta-analysis was performed to examine the relationship of fracture risk with Type 2 diabetes mellitus and gender. For this purpose, we searched the credible databases including PubMed, ISI, and Scopus for the related epidemiologic studies that were published up to May 2016. The data provided in these articles was extracted and then analyzed by a random-effects model. Funnel plot was used to check for publication bias. Statistical analyses were carried out by R version 3.2.1 and STATA (version 11.1). After filtering irrelevant articles, 30 studies were selected for meta-analysis. The analyses showed that type 2 diabetes mellitus is positively associated with overall fracture risk (summary RR. 1.05, 95 CI: 1.04, 1.06). The incidence of fractures was higher in men than in women (Phet=0.043). The interpretation of the meta-regression showed that no significant relationship exists between the gender risk factor in diabetic patients and years of study (P=0.280). The results highlight the importance of adopting suitable strategies for prevention of bone fracture in T2DM patients.

Item Type: Article
Mohamadpour, S.UNSPECIFIED
Shirzadpour, E.UNSPECIFIED
Mohamadpour, S.UNSPECIFIED
Keywords: Diabetes mellitus Bone Osteoporosis Fractures Meta-analysis population-based cohort hip fracture mineral density vertebral fractures osteoporotic fractures distal forearm older-adults elderly-men women type-1 Engineering Research & Experimental Medicine
Page Range: pp. 7793-7799
Journal or Publication Title: Biomedical Research-India
Journal Index: ISI
Volume: 28
Number: 18
ISSN: 0970-938X
Depositing User: مهندس مهدی شریفی

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