Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effect of Ammonium Chloride in addition to standard of care in outpatients and hospitalized COVID-19 patients: A randomized clinical trial

Thu Aug 18 00:07:43 2022

(2021) Effect of Ammonium Chloride in addition to standard of care in outpatients and hospitalized COVID-19 patients: A randomized clinical trial. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. pp. 306-308. ISSN 1878-3511 (Electronic) 1201-9712 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/33878462

Abstract

OBJECTIVE: The COVID-19 pandemic has called an urgent need for drug repurposing to improve the outcome of the disease. Quaternary ammonium compounds have been demonstrated to have antiviral effects and may be of use against SARS-CoV-2 infections. DESIGN: In this double-blind, single-center study, we enrolled patients with positive PCR test and/or CT findings for COVID-19. The participants of each group were randomly assigned to Diphenhydramine Compound (Diphenhydramine + Ammonium Chloride) plus standard of care or to Diphenhydramine alone and standard of care groups. The primary outcome was all-cause mortality within 30 days of randomization. Secondary outcomes include viral burden, clinical status, assessed by a 5-point ordinal scale, and length of stay in hospitalized patients. RESULTS: A total of 120 patients were included in the trial, 60 of which were assigned to the Ammonium Chloride group. The primary endpoint was not statistically different between the two groups (HR: 3.02 (95 CI, 0.57-16.06; p = 0.195)). Recovery time and viral burden were significantly lower in the Ammonium Chloride group, corresponding to an odds ratios of 1.8 (95 CI, 1.15-2.83; p = 0.01) and 7.90 (95 CI, 1.62-14.17; p = 0.014), respectively. CONCLUSION: The findings of this study advocate the careful addition of Ammonium Chloride to standard of care for COVID-19 patients.

Item Type: Article
Creators:
CreatorsEmail
Siami, Z.UNSPECIFIED
Aghajanian, S.UNSPECIFIED
Mansouri, S.UNSPECIFIED
Mokhames, Z.UNSPECIFIED
Pakzad, R.UNSPECIFIED
Kabir, K.UNSPECIFIED
Norouzi, M.UNSPECIFIED
Soleimani, A.UNSPECIFIED
Hedayat Yaghoobi, M.UNSPECIFIED
Shadabi, S.UNSPECIFIED
Tajbakhsh, R.UNSPECIFIED
Kargar Kheirabad, A.UNSPECIFIED
Mozhgani, S. H.UNSPECIFIED
Keywords: Ammonium Chloride Covid-19 Lysosomotropic agents Randomized clinical trial SARS-CoV-2
Divisions:
Page Range: pp. 306-308
Journal or Publication Title: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Journal Index: Pubmed
Volume: 108
Identification Number: https://doi.org/10.1016/j.ijid.2021.04.043
ISSN: 1878-3511 (Electronic) 1201-9712 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3483

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