Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates

Sun Oct 2 23:55:11 2022

(2021) Systematic review and meta-analysis of the epidemiology of vancomycin-resistance Staphylococcus aureus isolates. Antimicrobial resistance and infection control. p. 101. ISSN 2047-2994 (Electronic) 2047-2994 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/34193295

Abstract

BACKGROUND: Vancomycinresistant Staphylococcus aureus (VRSA) is a serious public health challenging concern worldwide. OBJECTIVES: Therefore, the objective of present study of 62 published studies was to evaluate the prevalence of VRSA based on different years, areas, isolate source, antimicrobial susceptibility testing, and the genetic determinants. METHODS: We searched the relevant articles that focused on the prevalence rates of VRSA in PubMed, Scopus, Embase, and Web of Science from 2000 to 2019. Statistical analyses were conducted using STATA software (version 14.0). RESULTS: The prevalence of VRSA was 2 before 2006, 5 in 2006-2014, and 7 in 2015-2020 that showed a 3.5-fold increase in the frequency of VRSA between before 2006 and 2020 years. The prevalence of VRSA was 5 in Asia, 1 in Europe, 4 in America, 3 in South America, and 16 in Africa. The frequencies of VRSA isolated from clinical, non-clinical, and mixed samples were 6, 7, and 14, respectively. The prevalence of VRSA was 12 using disk diffusion agar method, 7 using MIC-base methods, and 4 using mixed-methods. The prevalence of vanA, vanB, and vanC1 positive were 71, 26, and 4 among VRSA strains. The most prevalent genotype was staphylococcal cassette chromosomemec (SCCmec) II, which accounted for 57 of VRSA. The most prevalent staphylococcal protein A (spa) types were t002, t030, and t037. CONCLUSION: The prevalence of VRSA has been increasing in recent years particularly in Africa/Asia than Europe/America. The most prevalent of genetic determinants associated with VRSA were vanA and SCCmec II. This study clarifies that the rigorous monitoring of definite antibiotic policy, regular surveillance/control of nosocomial-associated infections and intensive surveillance of vancomycin-resistance are required for preventing emergence and further spreading of VRSA.

Item Type: Article
Creators:
CreatorsEmail
Wu, Q.UNSPECIFIED
Sabokroo, N.UNSPECIFIED
Wang, Y.UNSPECIFIED
Hashemian, M.UNSPECIFIED
Karamollahi, S.UNSPECIFIED
Kouhsari, E.UNSPECIFIED
Keywords: Antimicrobial resistance Systematic review and meta-analysis Vancomycinresistant Staphylococcus aureus
Divisions:
Page Range: p. 101
Journal or Publication Title: Antimicrobial resistance and infection control
Journal Index: Pubmed
Volume: 10
Number: 1
Identification Number: https://doi.org/10.1186/s13756-021-00967-y
ISSN: 2047-2994 (Electronic) 2047-2994 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3475

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