Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Solid-phase Extraction of Valproic Acid Using a Surfaced Imprinted Silica Gel Adsorbent

Mon Jun 24 05:06:08 2024

(2021) Solid-phase Extraction of Valproic Acid Using a Surfaced Imprinted Silica Gel Adsorbent. Chemical Methodologies. pp. 200-210. ISSN 2645-7776

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Using a solid-phase extraction for the determination of VPA, this study aimed to prepare a vaiproic acid (VPA) imprinted silica gel adsorbent by surface molecular imprinting technique. VPA-imprinted silica adsorbent was characterized by FTIR spectroscopy. The VPA adsorption from solutions was studied in SPE mode. All influenced parameters on adsorption efficiency, including the elution concentration, MW amount, VPA concentration, pH and salting effect, sample flow rate, column performance repeatability (relative standard deviation) were optimized independently. The prepared adsorbent showed significant adsorption capacity and selectivity for VPA. In the condition of sodium hydroxide solution (0.1 M), MW polymer (250 mg), VPA (10(-4) M), sample flow rate (1 ml min(-1)), pH around 2-6 in the presence of 4 NaCl, total VPA retention showed better reproducibility than 5. Recovery of VPA was about 94.6 to 98.1 and the relative standard deviation was less than 5.69. These results demonstrated that the prepared adsorbent can be used to measure VPA in biological samples. GRAPHICS .

Item Type: Article
Keywords: Valproic acid Silica gel Surface molecular imprinting Solid-phase extraction selective extraction antiepileptic drugs polymers ultrafiltration methodology adsorption aflatoxins sba-15 water Chemistry
Page Range: pp. 200-210
Journal or Publication Title: Chemical Methodologies
Journal Index: ISI
Volume: 5
Number: 2
Identification Number:
ISSN: 2645-7776
Depositing User: مهندس مهدی شریفی

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