Abstract

Objective Thalassemia is a public health challenge in the countries entitled belt thalassemia, but there is no pooled estimate of the survival rate on thalassemia major patients.The aim of this meta-analysis was to evaluate the pooled 10-, 15-, 20-, and 30-year survival rates of the patients with beta-thalassemia major around the world. Methods A comprehensive literature search of five international databases including Medline/PubMed, Scopus, Embase, Web of knowledge, and ProQuest was conducted to identify studies reporting survival rate of beta-thalassemia major until March 2020. Results From 714 retrieved studies, 7 studies with 8777 subjects were included in the meta-analysis. Base on random effect model, the 10-, 15-, 20-, and 30-year survival rates were 98.39, 95.07, 90.41, and 82.93 percent, respectively. Conclusions This meta-analysis provided acceptable results for estimating survival rate of beta-thalassemia compared to other studies. Hence, these results can be effectively used to develop and implement prevention and treatment interventions for policymakers.