Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Structure-genetic diversity and recombinant protein of circumsporozoite protein (CSP) of vivax malaria antigen: A potential malaria vaccine candidate

Thu Aug 18 11:59:57 2022

(2021) Structure-genetic diversity and recombinant protein of circumsporozoite protein (CSP) of vivax malaria antigen: A potential malaria vaccine candidate. Gene Reports. p. 6.

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Abstract

CSP surface protein is expressed by spores of different Plasmodium species. Plasmodium vivax CSP protein contains three domains. The first domain is the area before the central repeat areas or the pre-repeat area or area I. The second domain number of the region after the central repetition sequence or post-repeat region or region II and the third domain of the central replication region, which contains 14 to 19 replication sequences of 9 amino acids which includes three different types of VK210-VK247-vivax-like. Central replication regions in type VK210 include the GDRA D/A/P GQPA amino acid sequence and in type VK247 have the ANGA G(N/D)/DD QPG amino acid sequence. In all 3 types, the region before the repetition regions contains the amino acid sequence of KLKQPA (domain I). The region after the central repetition regions (domain II) contains the amino acid sequence. GGNAGG is EWTPCSVTCGVGVRVRRRVNAA. These areas are the epitopes of B and T cells and are candidates for vaccines.

Item Type: Article
Creators:
CreatorsEmail
Raissi, V.UNSPECIFIED
Etemadi, S.UNSPECIFIED
Getso, M. I.UNSPECIFIED
Mehravaran, A.UNSPECIFIED
Raiesi, O.UNSPECIFIED
Keywords: Circumsporozoite protein Plasmodium vivax Structure Genetic diversity recombinant protein Vaccine plasmodium-vivax pvcsp variants mosquito eastern region Genetics & Heredity
Divisions:
Page Range: p. 6
Journal or Publication Title: Gene Reports
Journal Index: ISI
Volume: 23
Identification Number: https://doi.org/10.1016/j.genrep.2021.101132
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3432

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