Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The efficacy of the ketogenic diet in infants and young children with refractory epilepsies using a formula-based powder

Sun Oct 2 08:00:04 2022

(2017) The efficacy of the ketogenic diet in infants and young children with refractory epilepsies using a formula-based powder. Acta Neurologica Belgica. pp. 175-182. ISSN 0300-9009

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Abstract

To evaluate the efficacy, safety, and tolerability of a classic 4:1 ketogenic diet using a formula-based powder in infants and children with refractory seizures who are reluctant to eat homemade foods. We conducted an open label trial and administered a ketogenic diet using formula-based power (Ketocal((R))). Twenty-seven infants and children aged between 12 months and 5 years were enrolled who had refractory seizures and were reluctant to eat homemade foods. Of 27 children, 5 were lost to follow-up and 22 were remained at the end of the study. After 4 months, the median frequency of seizures per week was reduced > 50 in 68.2 of patients, while 9/22 children (40.9) showed a 50-90 reduction in seizure frequency per week, and 6/22 children (27.3) showed more than 90 reduction in seizure frequency per week. Over the study course, 6/22 (27) children who continued to receive the diet developed constipation, one child developed gastroesophageal reflux, and one child developed hypercholesterolemia. None of these children discontinued the diet because of the complications. Thirteen children and their parents (59) reported that the diet was palatable and tolerable enough. The ketogenic diet using a formula-based powder (Ketocal((R))) is effective, safe, and tolerable in infants and children with refractory seizures who are reluctant to eat homemade foods according to the rules of the ketogenic diet.

Item Type: Article
Creators:
CreatorsEmail
Ashrafi, M.UNSPECIFIED
Hosseini, S.UNSPECIFIED
Zamani, G.UNSPECIFIED
Mohammadi, M.UNSPECIFIED
Tavassoli, A.UNSPECIFIED
Badv, R.UNSPECIFIED
Heidari, M.UNSPECIFIED
Karimi, P.UNSPECIFIED
Malamiri, R.UNSPECIFIED
Keywords: Infants Children Refractory epilepsy Ketogenic diet Ketocal (R) Efficacy childhood epilepsy dravet syndrome experience spasms Neurosciences & Neurology
Divisions:
Page Range: pp. 175-182
Journal or Publication Title: Acta Neurologica Belgica
Journal Index: ISI
Volume: 117
Number: 1
Identification Number: https://doi.org/10.1007/s13760-016-0732-0
ISSN: 0300-9009
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/342

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