Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Pd nanoparticles fabricated cyano-functionalized mesoporous SBA-15: A novel heterogeneous catalyst for Suzuki–Miyaura coupling reactions and anti-human lung cancer effects

Sun Oct 2 23:24:39 2022

(2021) Pd nanoparticles fabricated cyano-functionalized mesoporous SBA-15: A novel heterogeneous catalyst for Suzuki–Miyaura coupling reactions and anti-human lung cancer effects. Materials Chemistry and Physics. ISSN 02540584 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

A novel Pd (0) nanoparticles anchored over cyano modified SBA-15 was synthesized and characterized with different physicochemical techniques like Transmission Electron Microscopy (TEM), Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-ray Spectroscopy (EDX), N2 adsorption-desorption isotherm, X-ray elemental mapping and X-ray Photoelectron Spectroscopy (XPS). Pd content on the catalyst surface was determined to be 0.12 mmol/g by induced coupled plasma atomic emission spectroscopy (ICP-AES). The composite surface material was described as a novel heterogeneous nanocatalyst for the ligand-free C–C bond formation using Suzuki-Miyaura coupling at room temperature in air without the use of inert atmosphere. It afforded excellent yields in short reaction time. The catalyst was recovered and recycled 12 times without a significant loss of catalytic activity. To survey the cytotoxicity and anti-human lung cancer properties of catalyst, MTT assay was used on the common human lung cancer cell lines i.e., moderately differentiated adenocarcinoma of lung (LC-2/ad), poorly differentiated adenocarcinoma of lung (PC-14), and well-differentiated bronchogenic adenocarcinoma (HLC-1). The catalyst had high anti-human lung cancer and very low cell viability potentials dose-dependently against LC-2/ad, PC-14, and HLC-1 cell lines. The best result of anti-human lung cancer effects was observed in the case of the PC-14 cell line. After approving the above results in the clinical trial studies, catalyst may be used as a chemotherapeutic drug for the treatment of human lung cancer. © 2020 Elsevier B.V.

Item Type: Article
Creators:
CreatorsEmail
Wang, J.UNSPECIFIED
Wang, L.UNSPECIFIED
Cai, X.UNSPECIFIED
Karmakar, B.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Liu, H.UNSPECIFIED
Keywords: Chemotherapeutic drug Human lung cancer Pd(0) SBA-15 Suzuki-miyaura coupling Atomic emission spectroscopy Biological organs Cell culture Cells Diseases Drug delivery Energy dispersive spectroscopy Field emission microscopes High resolution transmission electron microscopy Human reaction time Nanocatalysts Nanoparticles Respiratory system Scanning electron microscopy Synthesis (chemical) X ray photoelectron spectroscopy Chemotherapeutic drugs Energy dispersive X ray spectroscopy Field emission scanning electron microscopy Heterogeneous catalyst Human lung cancer cell line Induced coupled plasmas Physicochemical techniques Catalyst activity
Divisions:
Journal or Publication Title: Materials Chemistry and Physics
Journal Index: Scopus
Volume: 257
Identification Number: https://doi.org/10.1016/j.matchemphys.2020.123375
ISSN: 02540584 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3408

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