Repository of Research and Investigative Information

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Ilam University of Medical Sciences

Characterization of antimicrobial resistance patterns of klebsiella pneu-moniae isolates obtained from wound infections

Thu Aug 11 16:41:19 2022

(2021) Characterization of antimicrobial resistance patterns of klebsiella pneu-moniae isolates obtained from wound infections. Infectious Disorders - Drug Targets. pp. 119-124. ISSN 18715265 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Multidrug resistance among ESBL producing isolates has limited the ad-ministration of proper antibiotics. It is, therefore, important to monitor the resistance patterns of Klebsiella pneumoniae isolates and provide infection control strategies to prevent nosocomial out-breaks. This study was aimed to determine antimicrobial resistance patterns of K. pneumoniae isolates obtained from wound infections of patients in Tehran, Iran. Methods: A total of 102 K. pneumoniae isolates were obtained from wound infections of patients in Tehran, Iran. The production of phenotypic ESBL and carbapenemase was assessed using the double-disc synergy test (DDST) and modified Hodge test (MHT), respectively. PCR was performed for the detection of ESBL, carbapenemase, quinolone and aminoglycoside resistance genes. Results: Forty-six (45.1) and 23 (22.5) isolates, out of the 102 isolates, were phenotypically detected as ESBL and carbapenemase producers, respectively. The PCR results showed that 80/102 (78.4) and 51/102 (50) isolates possessed at least one of the assessed ESBL and carbapene-mase genes, respectively. Quinolone resistance determinants (QRDs) and aac(6')-Ib genes were found amongst 50 (49) and 67 (65.7) isolates, respectively. Four isolates carried blaTEM, blaSHV, blaCTX-M, qnrB, qnrS and aac(6’)-Ib genes, simultaneously. Conclusion: Due to the presence of multiple resistance genes among some K. pneumoniae strains, antibiotic agents should be used with caution to preserve their efficacy in case of life-threatening in-fections. © 2021 Bentham Science Publishers.

Item Type: Article
Creators:
CreatorsEmail
Ghanavati, R.UNSPECIFIED
Kazemian, H.UNSPECIFIED
Asadollahi, P.UNSPECIFIED
Heidari, H.UNSPECIFIED
Irajian, G.UNSPECIFIED
Navab-Moghadam, F.UNSPECIFIED
Razavi, S.UNSPECIFIED
Keywords: Aminoglycoside Carbapenemase ESBL Klebsiella pneumoniae Quinolone Resistance genes amikacin ampicillin antibiotic agent beta lactamase AmpC carbapenem cefotaxime cefoxitin cefpodoxime ceftazidime ceftriaxone ciprofloxacin colistin extended spectrum beta lactamase gentamicin imipenem levofloxacin meropenem quinolone derivative tetracycline agar diffusion aminoglycoside resistance antibiotic resistance antibiotic sensitivity Article bacterial gene bacterium detection bacterium isolate controlled study disk diffusion drug efficacy Escherichia coli hospital patient human infection control Iran minimum inhibitory concentration molecular epidemiology multidrug resistance nonhuman phenotype polymerase chain reaction prevalence Staphylococcus aureus wound infection
Divisions:
Page Range: pp. 119-124
Journal or Publication Title: Infectious Disorders - Drug Targets
Journal Index: Scopus
Volume: 21
Number: 1
Identification Number: https://doi.org/10.2174/1871526520666200129124924
ISSN: 18715265 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3406

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