Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evaluation of type ii toxin-antitoxin systems, antibiotic resistance pro-files, and biofilm quorum sensing genes in acinetobacter baumannii isolates in Iraq

Sun Nov 27 21:50:30 2022

(2021) Evaluation of type ii toxin-antitoxin systems, antibiotic resistance pro-files, and biofilm quorum sensing genes in acinetobacter baumannii isolates in Iraq. Infectious Disorders - Drug Targets. pp. 187-193. ISSN 18715265 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Bacterial Toxin-Antitoxin (TAs) systems are extensive two-component el-ements in the bacterial genome, which are involved in many key biological functions, including growth arrest, survival, biofilm formation, plasmid maintenance, defense against phages, persis-tence, and virulence. Aim: This study aimed to assess the molecular determinants involved in TAs, biofilm quorum sens-ing, and antibiotic resistance profiles in Acinetobacter baumannii isolated from Baghdad’s hospitals in Iraq. Methods: A total of 127 A. baumannii isolates were collected from 2160 different clinical samples. The antimicrobial susceptibility test was performed using the disk diffusion test. All isolates were characterized for molecular determinants involved in TAs and biofilm formation using the well--known PCR-based sequencing assay. Results: A high multi-drug resistant (MDR) (96.06; 122/127) and imipenem resistance (84.25; 107/127) rates were observed from A.baumannii isolates. Results showed the presence of rhlIR gene in three isolates (2.36), and lasIR gene appeared in two isolates (1.57) isolates, whilst, mazEF, ccdAB, and relBE genes have not been detected among any of the isolates. Conclusion: A high MDR and imipenem resistance rates within a low prevalence of rhlIR, and lasIR genes could be found in clinical A. baumannii isolates from some of the Iraqi hospitals. © 2021 Bentham Science Publishers.

Item Type: Article
Creators:
CreatorsEmail
Al Marjania, M. F.UNSPECIFIED
Kouhsari, E.UNSPECIFIED
Ali, F. S.UNSPECIFIED
Authman, S. H.UNSPECIFIED
Keywords: Acinetobacter baumannii Antibiotics resistance Quorum sensing systems Toxin-antitoxin systems imipenem antibiotic sensitivity Article bacterial gene bacterial virulence bacteriophage bacterium identification bacterium isolate biofilm blood sampling body fluid burn ccdA ccdAB ccdB controlled study disk diffusion DNA extraction ear swab extensively drug resistant gene human Iraq lasI lasIR gene lasR maze test mazEF mazF mqsR multidrug resistant Acinetobacter baumannii pan drug resistant plasmid polymerase chain reaction prevalence quorum sensing relB relBE relE rhlI rhlIR rhlR sequence analysis sputum analysis toxin-antitoxin system urine sampling wound
Divisions:
Page Range: pp. 187-193
Journal or Publication Title: Infectious Disorders - Drug Targets
Journal Index: Scopus
Volume: 21
Number: 2
Identification Number: https://doi.org/10.2174/1871526520666200525170318
ISSN: 18715265 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3403

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