Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Sensitive sensor based on TiO2NPs nano-composite for the rapid analysis of Zolpidem, a psychoactive drug with cancer-causing potential

Thu Dec 1 18:03:24 2022

(2021) Sensitive sensor based on TiO2NPs nano-composite for the rapid analysis of Zolpidem, a psychoactive drug with cancer-causing potential. Materials Today Communications. ISSN 23524928 (ISSN)

Full text not available from this repository.

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

In the present study, a sensitive and specific electrochemical sensor is developed based on titanium dioxide and ionic liquid nano-composite (TiO2NPs/IL) for the measurement of Zolpidem (ZLP) as a hypnotic and sleep-promoting drug. The nano-composite provides high surface area and catalytic ability in ZLP oxidation at the modified carbon paste electrode (CPE). The obtained results of the differential pulse voltammetry (DPV) method reflect a wide linear range (0.1−90 μM) and an unprecedented limit of detection (LOD = 33 nM) for the ZLP sensor comparable with previously reported methods. The TiO2NPs/IL/CPE remarkably enriched the electrochemical response to ZLP oxidation and it has good stability, repeatability, and reproducibility. The TiO2NPs/IL/CPE is mechanically stable, cost-effective and simple, with suitable electrochemical and adsorption properties in comparison to the pencil graphite electrode (PGE) and glassy carbon electrode (GCE). The potential applicability of the sensor was successfully applied for distinguishing the ZLP in human plasma and drug formulation samples. © 2020

Item Type: Article
Creators:
CreatorsEmail
Sohouli, E.UNSPECIFIED
Ghalkhani, M.UNSPECIFIED
Shahdost-fard, F.UNSPECIFIED
Khosrowshahi, E. M.UNSPECIFIED
Rahimi-Nasrabadi, M.UNSPECIFIED
Ahmadi, F.UNSPECIFIED
Keywords: Differential pulse voltammetry Ionic liquid Modified electrode Nanocomposite Titanium dioxide nanoparticles Zolpidem Carbon Catalytic oxidation Cost effectiveness Electrochemical sensors Glass membrane electrodes Graphite electrodes Ionic liquids Nanocomposites TiO2 nanoparticles Titanium dioxide Voltammetry Adsorption properties Electrochemical response Glassy carbon electrodes Limit of detection Mechanically stable Modified carbon paste electrode Pencil graphite electrode Nanosensors
Divisions:
Journal or Publication Title: Materials Today Communications
Journal Index: Scopus
Volume: 26
Identification Number: https://doi.org/10.1016/j.mtcomm.2020.101945
ISSN: 23524928 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3397

Actions (login required)

View Item View Item