Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Green synthesis of NiO nanoparticles using Calendula officinalis extract: Chemical charactrization, antioxidant, cytotoxicity, and anti-esophageal carcinoma properties

Thu Aug 18 12:12:39 2022

(2021) Green synthesis of NiO nanoparticles using Calendula officinalis extract: Chemical charactrization, antioxidant, cytotoxicity, and anti-esophageal carcinoma properties. Arabian Journal of Chemistry. ISSN 18785352 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

In this study, nickel nanoparticles (NiONPs) have been successfully synthesized in an aqueous medium using the aqueous extract from the leaves of Calendula officinalis. The synthesized NiONPs were characterized using different techniques. According to the XRD analysis, the mean crystal size for NiONPs was found to be 33.17 nm. In addition, SEM images exhibited a uniform spherical morphology with a size of 60.39 nm for the NiONPs. The anti-esophageal carcinoma potentials of C. officinalis leaf aqueous extract, and NiONPs were assessed by the MTT assay against distal esophageal adenocarcinoma (FLO-1), gastroesophageal junction adenocarcinoma (ESO26), human caucasian esophageal carcinoma (OE33), and human esophageal squamous cell carcinoma (KYSE-270) cell lines. This study showed that NiONPs had excellent cell death and anti-cancer effects against esophageal carcinoma cell lines. The IC50 of NiONPs were 380, 263, 229, and 251 µg/mL against FLO-1, ESO26, OE33, and KYSE-270 cell lines, respectively. Among the studied cell lines, the best anti-esophageal cancer activities of NiONPs were gained in the cell line of OE33. The antioxidant activity of NiONPs was investigated using the DPPH test. In the antioxidant test, NiONPs prevented the oxidation of 50 of the DPPH molecules at a concentration of 204 µg/mL. Considering the obtained results, it can be suggested that NiONPs may be administrated as a chemotherapeutic supplement/drug to treat esophageal carcinoma. © 2021 The Author(s)

Item Type: Article
Creators:
CreatorsEmail
Zhang, Y.UNSPECIFIED
Mahdavi, B.UNSPECIFIED
Mohammadhosseini, M.UNSPECIFIED
Rezaei-Seresht, E.UNSPECIFIED
Paydarfard, S.UNSPECIFIED
Qorbani, M.UNSPECIFIED
Karimian, M.UNSPECIFIED
Abbasi, N.UNSPECIFIED
Ghaneialvar, H.UNSPECIFIED
Karimi, E.UNSPECIFIED
Keywords: Calendula officinalis Esophageal cancer In vitro condition Nickel nanoparticles Antioxidants Cell culture Cell death Nanoparticles Nickel oxide Synthesis (chemical) Aqueous extracts Calendula officinali Cell lines Esophageal carcinoma Green synthesis NiO nanoparticles Synthesised Diseases
Divisions:
Journal or Publication Title: Arabian Journal of Chemistry
Journal Index: Scopus
Volume: 14
Number: 5
Identification Number: https://doi.org/10.1016/j.arabjc.2021.103105
ISSN: 18785352 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3392

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