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Ilam University of Medical Sciences

Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review

Tue Aug 16 05:13:35 2022

(2021) Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review. European Journal of Clinical Microbiology & Infectious Diseases. p. 20. ISSN 0934-9723

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Abstract

Tigecycline is unique glycylcycline class of semisynthetic antimicrobial agents developed for the treatment of polymicrobial infections caused by multidrug-resistant Gram-positive and Gram-negative pathogens. Tigecycline evades the main tetracycline resistance genetic mechanisms, such as tetracycline-specific efflux pump acquisition and ribosomal protection, via the addition of a glycyclamide moiety to the 9-position of minocycline. The use of the parenteral form of tigecycline is approved for complicated skin and skin structure infections (excluding diabetes foot infection), complicated intra-abdominal infections, and community-acquired bacterial pneumonia in adults. New evidence also suggests the effectiveness of tigecycline for the treatment of severe Clostridioides difficile infections. Tigecycline showed in vitro susceptibility to Coxiella spp., Rickettsia spp., and multidrug-resistant Neisseria gonnorrhoeae strains which indicate the possible use of tigecycline in the treatment of infections caused by these pathogens. Except for intrinsic, or often reported resistance in some Gram-negatives, tigecycline is effective against a wide range of multidrug-resistant nosocomial pathogens. Herein, we summarize the currently available data on tigecycline pharmacokinetics and pharmacodynamics, its mechanism of action, the epidemiology of tigecycline resistance, and its clinical effectiveness.

Item Type: Article
Creators:
CreatorsEmail
Yaghoubi, S.UNSPECIFIED
Zekiy, A. O.UNSPECIFIED
Krutova, M.UNSPECIFIED
Gholami, M.UNSPECIFIED
Kouhsari, E.UNSPECIFIED
Sholeh, M.UNSPECIFIED
Ghafouri, Z.UNSPECIFIED
Maleki, F.UNSPECIFIED
Keywords: Tigecycline resistance Tigecycline antibacterial activity Tigecycline clinical Effectiveness in-vitro activity multidrug efflux pump ventilator-associated pneumonia multiple antibiotic-resistance exposure-response analyses bacteroides-fragilis group induced acute-pancreatitis gram-negative pathogens acinetobacter-baumannii antimicrobial susceptibility Infectious Diseases Microbiology
Divisions:
Page Range: p. 20
Journal or Publication Title: European Journal of Clinical Microbiology & Infectious Diseases
Journal Index: ISI
Identification Number: https://doi.org/10.1007/s10096-020-04121-1
ISSN: 0934-9723
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3332

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