Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Bismuth oxide nanoparticles as agents of radiation dose enhancement in intraoperative radiotherapy

Thu Aug 18 11:46:12 2022

(2021) Bismuth oxide nanoparticles as agents of radiation dose enhancement in intraoperative radiotherapy. Medical Physics. pp. 1417-1426. ISSN 0094-2405

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Abstract

Purpose Intraoperative radiotherapy (IORT) technique is an advanced radio therapeutic method used for delivery of a single high-dose radiation during surgery while removing healthy tissues from the radiation field. Nowadays, growing attention is being paid to IORT for its low-energy (kilovoltage) delivery as it requires less radiation protection, but suffers several disadvantages, including high-dose delivery and prolonged treatment time. The application of nanoparticles with high atomic number and high attenuation coefficients in kilovoltage energy may help overcome the mentioned shortcomings. This study was designed to investigate and quantify the mean dose enhancement factor (DEF) in the presence of nanoparticles using IORT method. Methods Bismuth oxide nanoparticles (Bi(2)O(3)NPs), both in sheet and spherical formats, were synthesized using a novel hydrothermal method and characterized with x-ray diffraction (XRD), transmission electron microscopy (TEM), and Brunauer-Emmett-Teller (BET) analysis. Genipin-gelatin gel dosimeter (GENIPIN) was produced in three batches of pure with sheet and with spherical nanoparticles in concentration of 46.596 mu g/ml, and irradiated with 50 kV x-rays. Results Samples were scanned by a spectrophotometer, which indicated a DEF of 3.28 +/- 0.37 and 2.50 +/- 0.23 for sheet and spherical NPs, respectively. According to the results of this study, GENIPIN is a suitable dosimeter for the evaluation of three-dimensional dose distribution in the presence Bi2O3 NPs. Conclusion As a result, IORT along with Bi2O3 NPs has the potential to reduce treatment time and/or normal tissue dose; moreover, it could provide localized dose enhancement.

Item Type: Article
Creators:
CreatorsEmail
Nezhad, Z. A.UNSPECIFIED
Geraily, G.UNSPECIFIED
Hataminia, F.UNSPECIFIED
Parwaie, W.UNSPECIFIED
Ghanbari, H.UNSPECIFIED
Gholami, S.UNSPECIFIED
Keywords: bismuth oxide dose enhancement GENIPIN gel dosimeter IORT Nanomedicine Radiology, Nuclear Medicine & Medical Imaging
Divisions:
Page Range: pp. 1417-1426
Journal or Publication Title: Medical Physics
Journal Index: ISI
Volume: 48
Number: 3
Identification Number: https://doi.org/10.1002/mp.14697
ISSN: 0094-2405
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3321

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