Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Effect of Sevoflurane Plus Propofol on Pain and Complications after Laminectomy: A Randomized Double-Blind Clinical Trial

Fri Dec 2 17:29:16 2022

(2017) The Effect of Sevoflurane Plus Propofol on Pain and Complications after Laminectomy: A Randomized Double-Blind Clinical Trial. Journal of Clinical and Diagnostic Research. UC5-UC8. ISSN 2249-782X

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Abstract

Introduction: Pain is one of the most important reasons for the patients concern after surgery. The perfect sedative should have properties like rapid onset, least pain and adverse effects. Aim: To assess the effect of sevoflurane plus propofol on postoperative pain, haemodynamic stability and complication after lumbar disc surgery. Materials and Methods: This was a randomized double-blind clinical trial. A total of 75 patients scheduled for elective lumbar disc surgery with simple random sampling design received sevoflurane (n= 25, induced with Thiopentone and maintained with sevoflurane), propofol (n= 25, induced and maintained with propofol) and sevoflurane plus propofol (n= 25, induced with propofol and maintained with sevoflurane). Visual Analog Scale (VAS) was used to determine the intensity of postoperative pain. Complications after surgery and haemodynamic changes during surgery were recorded. Results: The mean pain intensity and morphine consumption in the sevoflurane plus propofol group was lower compared to the propofol and sevoflurane group sat different intervals (P < 0.001). The prevalence of shivering, nausea and vomiting in the sevoflurane plus propofol group was 24, 28, 28 respectively vs sevoflurane group 32, 60, 48 respectively and propofol group 32, 16, 12 respectively with p-value > 0.05, < 0.001, < 0.05 respectively. The mean blood pressure and heart rate were significantly lower in the sevoflurane plus propofol group compared to the propofol and sevoflurane groups (p < 0.001). Conclusion: According to the effect on pain and complications after lumbar disc surgery sevoflurane plus propofol can be regarded as safe and alternative drug in general anaesthesia for these patients.

Item Type: Article
Creators:
CreatorsEmail
Vasigh, A.UNSPECIFIED
Najafi, F.UNSPECIFIED
Jaafarpour, M.UNSPECIFIED
Khajavikhan, J.UNSPECIFIED
Khani, A.UNSPECIFIED
Keywords: Anaesthesia Lumbar disc surgery Visual analog scale interventional neuroradiology lumbar laminectomy postoperative pain anesthesia isoflurane pregabalin desflurane surgery General & Internal Medicine
Divisions:
Page Range: UC5-UC8
Journal or Publication Title: Journal of Clinical and Diagnostic Research
Journal Index: ISI
Volume: 11
Number: 4
Identification Number: https://doi.org/10.7860/jcdr/2017/23565.9643
ISSN: 2249-782X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/332

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