Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

In vitro antibacterial activity and durability of a nano-curcumin-containing pulp capping agent combined with antimicrobial photodynamic therapy

Mon Jun 27 15:32:28 2022

(2021) In vitro antibacterial activity and durability of a nano-curcumin-containing pulp capping agent combined with antimicrobial photodynamic therapy. Photodiagnosis and Photodynamic Therapy. p. 7. ISSN 1572-1000

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Abstract

Background: Considering the antibacterial properties of nano-curcumin (nCur) reinforced with antimicrobial photodynamic therapy (aPDT), this study aimed to assess the antibacterial activity and durability of Activa BioActive Base/Liner (ABBL) containing nCur (nCur-ABBL) as a pulp capping agent against Streptococcus mutans, the most common cause of secondary caries. Materials and methods: In this in vitro experimental study, ABBL discs containing 0.5 , 1, 2, and 5 (w/w) concentrations of nCur were fabricated. After aPDT using light emitting diode (LED) at 435 +/- 20 nm wavelength for 5 min, the discs were undergone aging in artificial saliva for 90 days. The antibacterial activity of the discs against S. mutans was evaluated by the disc agar diffusion test, and the number of bacterial colonies present in the biofilm formed on the disc surfaces was counted after 0, 15, 30, and 60 days of aging. Results: The maximum growth inhibition zone was noted around the 5 nCur-ABBL discs. Increasing the con-centration of nCur from 0.5 to 5 combined with aPDT significantly decreased the number of S. mutans colonies in the biofilm over time (P < 0.05). nCur-ABBL discs containing 2 and 5 nCur had no difference in antibacterial activity at any time point up to 60 days (P > 0.05). Conclusion: According to our data, 5 nCur-ABBL revealed the largest growth inhibition zone in S. mutans culture. Moreover, 5 nCur can serve as an excellent ABBL additive in aPDT producer against S. mutans biofilms up to 60 days of aging period.

Item Type: Article
Creators:
CreatorsEmail
Pourhajibagher, M.UNSPECIFIED
Omrani, L. R.UNSPECIFIED
Noroozian, M.UNSPECIFIED
Ghorbanzadeh, Z.UNSPECIFIED
Bahador, A.UNSPECIFIED
Keywords: Pulp capping Antimicrobial photodynamic therapy Nano-curcumin Activa BioActive Base Liner tooth discoloration caries cement cells Oncology
Divisions:
Page Range: p. 7
Journal or Publication Title: Photodiagnosis and Photodynamic Therapy
Journal Index: ISI
Volume: 33
Identification Number: https://doi.org/10.1016/j.pdpdt.2020.102150
ISSN: 1572-1000
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3312

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