Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Persister cells as a possible cause of antibiotic therapy failure in Helicobacter pylori

Sun Sep 25 12:31:10 2022

(2021) Persister cells as a possible cause of antibiotic therapy failure in Helicobacter pylori. Jgh Open. p. 5. ISSN 2397-9070

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Abstract

Background and Aim: Due to the failure of antibiotic treatment and recurrence of infection in patients with Helicobacter pylori, this study was designed to find the possible cause of treatment failure and recurrence of the H. pylori infections in Ilam, Iran. Methods: One hundred patients with specific symptoms of H. pylori infection were selected, and after taking a biopsy specimen, identification of H. pylori, antibiotic susceptibility assay, and persister cell assay were performed. In addition, after treatment, patients with persister cells were followed for possible recurrence of infection. Furthermore, an antibiotic susceptibility assay was performed. Results: Our results demonstrated that, among 100 patients, 50 (n = 50) showed positive results for the existence of H. pylori. Among the susceptible isolates, 18 (n = 9) were persister cells that were sensitive to clarithromycin as confirmed by a 5 folds higher than the Minimal Inhibitory Concentration (MIC) of clarithromycin. The data were confirmed by following up the suspected patients. Conclusion: Our results demonstrated that persister cells in H. pylori infections may be responsible to recurrent infection and antibiotic treatment failure. However, more research is needed to obtain more information in this area.

Item Type: Article
Creators:
CreatorsEmail
Bahmaninejad, P.UNSPECIFIED
Ghafourian, S.UNSPECIFIED
Mahmoudi, M.UNSPECIFIED
Maleki, A.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Badakhsh, B.UNSPECIFIED
Keywords: drug tolerance Helicobacter pylori reinfection Gastroenterology & Hepatology
Divisions:
Page Range: p. 5
Journal or Publication Title: Jgh Open
Journal Index: ISI
Identification Number: https://doi.org/10.1002/jgh3.12527
ISSN: 2397-9070
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3310

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