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Ilam University of Medical Sciences

The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017

Thu Dec 1 17:44:55 2022

(2020) The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017. The Lancet Gastroenterology and Hepatology. pp. 582-597. ISSN 24681253 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background Oesophageal cancer is a common and often fatal cancer that has two main histological subtypes: oesophageal squamous cell carcinoma and oesophageal adenocarcinoma. Updated statistics on the incidence and mortality of oesophageal cancer, and on the disability-adjusted life-years (DALYs) caused by the disease, can assist policy makers in allocating resources for prevention, treatment, and care of oesophageal cancer. We report the latest estimates of these statistics for 195 countries and territories between 1990 and 2017, by age, sex, and Socio-demographic Index (SDI), using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD). Methods We used data from vital registration systems, vital registration-samples, verbal autopsy records, and cancer registries, combined with relevant modelling, to estimate the mortality, incidence, and burden of oesophageal cancer from 1990 to 2017. Mortality-to-incidence ratios (MIRs) were estimated and fed into a Cause of Death Ensemble model (CODEm) including risk factors. MIRs were used for mortality and non-fatal modelling. Estimates of DALYs attributable to the main risk factors of oesophageal cancer available in GBD were also calculated. The proportion of oesophageal squamous cell carcinoma to all oesophageal cancers was extracted by use of publicly available data, and its variation was examined against SDI, the Healthcare Access and Quality (HAQ) Index, and available risk factors in GBD that are specific for oesophageal squamous cell carcinoma (eg, unimproved water source and indoor air pollution) and for oesophageal adenocarcinoma (gastro-oesophageal reflux disease). Findings There were 473 000 (95 uncertainty interval 95% UI 459 000-485 000) new cases of oesophageal cancer and 436 000 (425 000-448 000) deaths due to oesophageal cancer in 2017. Age-standardised incidence was 5.9 (5.7-6.1) per 100 000 population and age-standardised mortality was 5.5 (5.3-5.6) per 100 000. Oesophageal cancer caused 9.78 million (9.53-10.03) DALYs, with an age-standardised rate of 120 (117-123) per 100 000 population. Between 1990 and 2017, age-standardised incidence decreased by 22.0% (18.6-25.2), mortality decreased by 29.0% (25.8-32.0), and DALYs decreased by 33.4% (30.4-36.1) globally. However, as a result of population growth and ageing, the total number of new cases increased by 52.3% (45.9-58.9), from 310 000 (300 000-322 000) to 473 000 (459 000-485 000); the number of deaths increased by 40.0% (34.1-46.3), from 311 000 (301 000-323 000) to 436 000 (425 000-448 000); and total DALYs increased by 27.4% (22.1-33.1), from 7.68 million (7.42-7.97) to 9.78 million (9.53-10.03). At the national level, China had the highest number of incident cases (235 000 223 000-246 000), deaths (213 000 203 000-223 000), and DALYs (4.46 million 4.25-4.69) in 2017. The highest national-level agestandardised incidence rates in 2017 were observed in Malawi (23.0 19.4-26.5 per 100 000 population) and Mongolia (18.5 16.4-20.8 per 100 000). In 2017, age-standardised incidence was 2.7 times higher, mortality 2.9 times higher, and DALYs 3.0 times higher in males than in females. In 2017, a substantial proportion of oesophageal cancer DALYs were attributable to known risk factors: tobacco smoking (39.0% 35.5-42.2), alcohol consumption (33.8% 27.3-39.9), high BMI (19.5% 6.3-36.0), a diet low in fruits (19.1% 4.2-34.6), and use of chewing tobacco (7.5% 5.2-9.6). Countries with a low SDI and HAQ Index and high levels of indoor air pollution had a higher proportion of oesophageal squamous cell carcinoma to all oesophageal cancer cases than did countries with a high SDI and HAQ Index and with low levels of indoor air pollution. Interpretation Despite reductions in age-standardised incidence and mortality rates, oesophageal cancer remains a major cause of cancer mortality and burden across the world. Oesophageal cancer is a highly fatal disease, requiring increased primary prevention efforts and, possibly, screening in some high-risk areas. Substantial variation xists in age-standardised incidence rates across regions and countries, for reasons that are unclear. © 2020 The Author(s).

Item Type: Article
Creators:
CreatorsEmail
Kamangar, F. ProfUNSPECIFIED
Nasrollahzadeh, D.UNSPECIFIED
Safiri, S.UNSPECIFIED
Sepanlou, S. G.UNSPECIFIED
Fitzmaurice, C.UNSPECIFIED
Ikuta, K. S.UNSPECIFIED
Bisignano, C.UNSPECIFIED
Islami, F.UNSPECIFIED
Roshandel, G.UNSPECIFIED
Lim, S. S. ProfUNSPECIFIED
Abolhassani, H.UNSPECIFIED
Abu-Gharbieh, E.UNSPECIFIED
Adedoyin, R. A. ProfUNSPECIFIED
Advani, S. M.UNSPECIFIED
Ahmed, M. B.UNSPECIFIED
Aichour, M. T. E.UNSPECIFIED
Akinyemiju, T.UNSPECIFIED
Akunna, C. J.UNSPECIFIED
Alahdab, F.UNSPECIFIED
Alipour, V.UNSPECIFIED
Almasi-Hashiani, A.UNSPECIFIED
Almulhim, A. M.UNSPECIFIED
Anber, N. H.UNSPECIFIED
Ansari-Moghaddam, A. ProfUNSPECIFIED
Arabloo, J.UNSPECIFIED
Arab-Zozani, M.UNSPECIFIED
Awedew, A. F.UNSPECIFIED
Badawi, A.UNSPECIFIED
Berfield, K. S. S.UNSPECIFIED
Berhe, K.UNSPECIFIED
Bhattacharyya, K.UNSPECIFIED
Biondi, A. ProfUNSPECIFIED
Bjørge, T. ProfUNSPECIFIED
Borzì, A. M.UNSPECIFIED
Bosetti, C.UNSPECIFIED
Carreras, G.UNSPECIFIED
Carvalho, F. ProfUNSPECIFIED
Castro, C. ProfUNSPECIFIED
Chu, D. T.UNSPECIFIED
Costa, V. M.UNSPECIFIED
Dagnew, B.UNSPECIFIED
Gela, J. D.UNSPECIFIED
Daryani, A. ProfUNSPECIFIED
Demeke, F. M.UNSPECIFIED
Demoz, G. T.UNSPECIFIED
Dianatinasab, M.UNSPECIFIED
Elbarazi, I.UNSPECIFIED
Emamian, M. H.UNSPECIFIED
Etemadi, A.UNSPECIFIED
Faris, P. S.UNSPECIFIED
Fernandes, E. ProfUNSPECIFIED
Filip, I.UNSPECIFIED
Fischer, F.UNSPECIFIED
Gad, M. M.UNSPECIFIED
Gallus, S.UNSPECIFIED
Gebre, A. K.UNSPECIFIED
Gebrehiwot, T. T.UNSPECIFIED
Gebremeskel, G. G.UNSPECIFIED
Gebresillassie, B. M.UNSPECIFIED
Ghasemi-Kebria, F.UNSPECIFIED
Ghashghaee, A.UNSPECIFIED
Ghith, N.UNSPECIFIED
Golechha, M.UNSPECIFIED
Gorini, G.UNSPECIFIED
Gupta, R. ProfUNSPECIFIED
Hafezi-Nejad, N.UNSPECIFIED
Haj-Mirzaian, A.UNSPECIFIED
Harvey, J. D.UNSPECIFIED
Hashemian, M.UNSPECIFIED
Hassen, H. Y.UNSPECIFIED
Hay, S. I. ProfUNSPECIFIED
Henok, A.UNSPECIFIED
Hoang, C. L.UNSPECIFIED
Hosgood, H. D.UNSPECIFIED
Househ, M. ProfUNSPECIFIED
Ilesanmi, O. S.UNSPECIFIED
Ilic, M. D. ProfUNSPECIFIED
Irvani, S. S. N.UNSPECIFIED
Jain, C.UNSPECIFIED
James, S. L.UNSPECIFIED
Jee, S. H.UNSPECIFIED
Jha, R. P.UNSPECIFIED
Joukar, F.UNSPECIFIED
Kabir, A.UNSPECIFIED
Kasaeian, A.UNSPECIFIED
Kassaw, M. W.UNSPECIFIED
Kaur, S.UNSPECIFIED
Kengne, A. P. ProfUNSPECIFIED
Kerboua, E. ProfUNSPECIFIED
Khader, Y. S. ProfUNSPECIFIED
Khalilov, R. ProfUNSPECIFIED
Khan, E. A.UNSPECIFIED
Khoja, A. T.UNSPECIFIED
Kocarnik, J. M.UNSPECIFIED
Komaki, H.UNSPECIFIED
Kumar, V.UNSPECIFIED
La Vecchia, C. ProfUNSPECIFIED
Lasrado, S.UNSPECIFIED
Li, B.UNSPECIFIED
Lopez, A. D. ProfUNSPECIFIED
othersUNSPECIFIED
Keywords: adult Africa south of the Sahara alcohol consumption Article Asia Australia Austria autopsy biomass body mass Canada cancer incidence cancer mortality cancer risk China demography disability-adjusted life year education esophagus cancer ethnicity female fertility gastroesophageal reflux Germany global disease burden health care access health care quality human indoor air pollution Kazakhstan Kyrgyzstan Latvia low income country major clinical study male medical care Middle East middle income country mortality rate North Africa priority journal risk factor smoking South and Central America squamous cell carcinoma Turkmenistan United States Uzbekistan Western Europe adenocarcinoma adolescent aged diet drinking behavior esophagus tumor middle aged obesity quality adjusted life year tobacco use very elderly young adult Aged, 80 and over Air Pollution, Indoor Alcohol Drinking Carcinoma, Squamous Cell Esophageal Neoplasms Global Burden of Disease Humans Overweight Quality-Adjusted Life Years Risk Factors
Divisions:
Page Range: pp. 582-597
Journal or Publication Title: The Lancet Gastroenterology and Hepatology
Journal Index: Scopus
Volume: 5
Number: 6
Identification Number: https://doi.org/10.1016/S2468-1253(20)30007-8
ISSN: 24681253 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3288

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