(2020) Polyvinyl alcohol/Gum tragacanth/graphene oxide composite nanofiber for antibiotic delivery. Journal of Drug Delivery Science and Technology. ISSN 17732247 (ISSN)
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Abstract
A mix of two synthetic and natural polymers (polyvinyl alcohol and gum tragacanth) blended with tetracycline containing graphene oxide were used to generate electrospun nanofiber scaffolds which can be used as a transdermal drug delivery system. The physicochemical properties of the nanofiber scaffolds were investigated using SEM, FTIR, XRD and tensile tests. The SEM analysis of nanofiber indicated that the diameter of obtained nanofibers was found to below 100 nm. The result of tensile test showed that the addition of graphene oxide increases the mechanical strength of nanofibers. MTT assay was done to investigate the cell viability of the PVA/GT/GO/TCH nanofiber against the normal cell lines (HUVECs), as well as Agar disk diffusion experiments were applied to determine the antibacterial activity. The results of cytotoxicity assay revealed high cell viability of PVA/GT/GO/TCH nanofiber against HUVECs. In the antimicrobial part of this research, this nanofiber composite indicated higher antibacterial effect than other used materials. © 2020 Elsevier B.V.
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| Keywords: | Drug delivery Graphene oxide Gum tragacanth Nanofiller Polymeric nanocomposites molecular scaffold nanocomposite polyvinyl alcohol tetracycline agar diffusion antibacterial activity Article Bacillus subtilis biocompatibility biodegradability cell viability chemical structure controlled drug release controlled study cytotoxicity assay disk diffusion electrospinning Enterococcus faecalis Escherichia coli Fourier transform infrared spectroscopy human human cell HUVEC cell line Listeria monocytogenes mechanics MTT assay nanopharmaceutics nonhuman physical chemistry Proteus mirabilis Pseudomonas aeruginosa Salmonella enterica serovar Typhimurium scanning electron microscopy Shigella flexneri Staphylococcus aureus Staphylococcus saprophyticus Streptococcus pneumoniae Streptococcus pyogenes synthesis tensile strength wound healing X ray diffraction | ||||||||||||||||||
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| Journal or Publication Title: | Journal of Drug Delivery Science and Technology | ||||||||||||||||||
| Journal Index: | Scopus | ||||||||||||||||||
| Volume: | 60 | ||||||||||||||||||
| Identification Number: | https://doi.org/10.1016/j.jddst.2020.102044 | ||||||||||||||||||
| ISSN: | 17732247 (ISSN) | ||||||||||||||||||
| Depositing User: | مهندس مهدی شریفی | ||||||||||||||||||
| URI: | http://eprints.medilam.ac.ir/id/eprint/3273 |
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