Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Chemical Composition and Anti-mycobacterial Activities of Trachyspermum copticum and Pelargonium graveolens Essential Oils

Thu Dec 8 07:05:09 2022

(2020) The Chemical Composition and Anti-mycobacterial Activities of Trachyspermum copticum and Pelargonium graveolens Essential Oils. Recent patents on anti-infective drug discovery. pp. 68-74. ISSN 2212-4071 (Electronic) 1574-891X (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/31657682

Abstract

BACKGROUND: Microbial resistance to antibiotics and their adverse effects related to these antibiotics are a matter of global public health in the 21th century. The emergence of drug-resistant strains, has gained the interest of the scientists to discover new antimicrobial agents from the essential oil of medicinal plants. METHODS: Anti-mycobacterial effects of Trachyspermum copticum and Pelargonium graveolens essential oils were determined against multi-drug resistant clinical strains of Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium fortuitum and standard strain of Mycobacterium tuberculosis H37Rv by a Broth micro-dilution method. Pelargonium graveolens plant named Narmada was discovered by Kulkarni R.N et al. (Patent ID, USPP12425P2) and a formulation comprising thymol obtained from Trachyspermum is useful in the treatment of drug-resistant bacterial infections (Patent ID, US6824795B2). The chemical composition of hydro-distilled essential oils was determined by GC and GC-MS. RESULTS: Minimum Inhibitory Concentration (MIC) values for T. copticum essential oil against tested isolates were ranged from 19.5 microg/mL to 78 microg/mL. The least minimum inhibitory concentration of P. graveolens extract against M. Kansasii and MDR-TB was 78 microg/ml. CONCLUSION: The results of the present research introduced T. copticum and P. graveolens essential oils as a remarkable natural anti-mycobacterial agent, but more pharmacological studies are required to evaluate their efficacy in animal models.

Item Type: Article
Creators:
CreatorsEmail
Kardan-Yamchi, J.UNSPECIFIED
Mahboubi, M.UNSPECIFIED
Kazemian, H.UNSPECIFIED
Hamzelou, G.UNSPECIFIED
Feizabadi, M. M.UNSPECIFIED
Keywords: Mycobacterium tuberculosis Pelargonium graveolens Trachyspermum copticum antimycobacterial activity chemical composition essential oil
Divisions:
Page Range: pp. 68-74
Journal or Publication Title: Recent patents on anti-infective drug discovery
Journal Index: Pubmed
Volume: 15
Number: 1
Identification Number: https://doi.org/10.2174/1574891X14666191028113321
ISSN: 2212-4071 (Electronic) 1574-891X (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3266

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