Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Distribution of invasive fungal infections: Molecular epidemiology, etiology, clinical conditions, diagnosis and risk factors: A 3-year experience with 490 patients under intensive care

Tue Jul 23 03:16:41 2024

(2020) Distribution of invasive fungal infections: Molecular epidemiology, etiology, clinical conditions, diagnosis and risk factors: A 3-year experience with 490 patients under intensive care. Microbial pathogenesis. p. 104616. ISSN 1096-1208 (Electronic) 0882-4010 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/33212195

Abstract

Recently, the prevalence of invasive fungal infections (IFIs) is rising. The global mortality rate of IFIs is 10-49. This study aimed to determine the prevalence, the causative agents, and the risk factors associated with the invasive fungal infections in a tertiary health center to provide valid decision-grounds for healthcare professionals to effectively prevent, control, and treat fungal infections. The current study was conducted on 1477 patients suspected to have systemic fungal infections from different units of the hospital. After screening using routine mycological examination, the patients were confirmed with complementary mycological and molecular methods. Patients were included based on the confirmed diagnosis of IFI and excluded based on lack of a microbiologically and histologically proven diagnosis of IFI. Of the 1477 patients recruited in this study, confirmed cases of fungal infection were 490 (169 proven; 321 cases probable). Among the fungi recovered, Candida species had the highest frequency 337 (68.8) followed by Aspergillus species 108 (22.1), Zygomycetes species 21 (4.3), non-Candida yeast 9 (1.8). Others were black fungi 5 (1), mycetoma agents 5 (1), Fusarium 4 (0.8), and Trichoderma (0.2). Hematologic malignancies and diabetes mellitus were the most common underlying diseases among IFI-confirmed patients. This study observed an increased frequency of invasive candidiasis with non-albicans Candida and other invasive saprophytic fungal infections. The increased rate of invasive candidiasis with non-albicans agents highlights a new perspective in the epidemiology and treatment of invasive fungal infections.

Item Type: Article
Creators:
CreatorsEmail
Borjian Boroujeni, Z.UNSPECIFIED
Shamsaei, S.UNSPECIFIED
Yarahmadi, M.UNSPECIFIED
Getso, M. I.UNSPECIFIED
Salimi Khorashad, A.UNSPECIFIED
Haghighi, L.UNSPECIFIED
Raissi, V.UNSPECIFIED
Zareei, M.UNSPECIFIED
Saleh Mohammadzade, A.UNSPECIFIED
Moqarabzadeh, V.UNSPECIFIED
Soleimani, A.UNSPECIFIED
Raeisi, F.UNSPECIFIED
Mohseni, M.UNSPECIFIED
Mohseni, M. S.UNSPECIFIED
Raiesi, O.UNSPECIFIED
Keywords: Aspergillus spp Candida spp Intensive care Invasive fungal infections Molecular epidemiology Risk factors
Divisions:
Page Range: p. 104616
Journal or Publication Title: Microbial pathogenesis
Journal Index: Pubmed
Identification Number: https://doi.org/10.1016/j.micpath.2020.104616
ISSN: 1096-1208 (Electronic) 0882-4010 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3246

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