Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Prevalence of Shiga toxin-1 in non-Shigella dysenteriae isolates collected from diarrhea samples in patients, Ahvaz, Iran

Wed Nov 30 06:32:10 2022

(2020) The Prevalence of Shiga toxin-1 in non-Shigella dysenteriae isolates collected from diarrhea samples in patients, Ahvaz, Iran. Infectious disorders drug targets. ISSN 2212-3989 (Electronic) 1871-5265 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/33292146

Abstract

BACKGROUND: Acute diarrhea is a major public health problem particularly in developing countries. Shigellosis is one of the substantial causative agents of microbial dysentery and still has a remarkable prevalence particularly in areas with poor hygienic infrastructures. The probable existence of the deadly Shiga toxin (Stx) protein in some Shigella strains would manifest life-threatening clinical symptoms of the infection. METHODS: The aim of this study was to determine the presence of Shigella toxin 1 (Stx1) in isolated from patients with diarrhea. Totally, 227 Shigella species including 60 S. flexneri, 157 S. sonnei, and 10 S. boydii were collected from diarrheal patients in tropical infectious diseases research center of Ahvaz, Iran, during 2013-2015. The isolates were collected mostly from the intensive care unit, infectious disease, and surgery settings. The isolates were identified and the polymerase chain reaction (PCR) was performed to detect the stx gene. RESULTS: The results indicated that none of them encode the stx1 gene. CONCLUSION: Isolates of this study were not capable of stx1 encoding. Future investigations should consider the relations between other Shigella species and Shigella toxin in Iran.

Item Type: Article
Creators:
CreatorsEmail
Mahdian, N.UNSPECIFIED
Kouhsari, E.UNSPECIFIED
Gheysarzadeh, A.UNSPECIFIED
Maleki, A.UNSPECIFIED
Valadbeigi, H.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Keywords: S. boydii S. flexneri S. sonnei Shiga Toxin Shigella species Stx1
Divisions:
Journal or Publication Title: Infectious disorders drug targets
Journal Index: Pubmed
Identification Number: https://doi.org/10.2174/1871526520666201207122924
ISSN: 2212-3989 (Electronic) 1871-5265 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3236

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