Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Investigating the Effect of Saffron Petal Extract on Antioxidant Activity and Inflammatory Markers in Hypercholesterolemic Rats

Fri Apr 12 19:20:39 2024

(2020) Investigating the Effect of Saffron Petal Extract on Antioxidant Activity and Inflammatory Markers in Hypercholesterolemic Rats. Entomology and Applied Science Letters. pp. 13-22. ISSN 2349-2864

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Abstract

Introduction: High-cholesterol diet is one of the major causes of cardiovascular disease leading to the death of millions of people annually. One of the ways to prevent this risk is the use of chemical drugs, but herbal compounds at controlled levels have less adverse effects than chemical compounds. In the present study, we investigated the effect of hydroalcoholic extract of a saffron petal on malondialdehyde (MDA) and superoxide dismutase (SOD) enzymes, inflammatory markers and lipid profile and compared it with lovastatin in hypercholesterolemic rats. Materials and Methods: Thirty adult Wistar rats were randomly divided into 6 equal groups (n = 5). Group 1 (sham) received a normal diet and Group 2 (control) received only a high-cholesterol diet (2). Group 3 to 6 were treated with a high-cholesterol diet (2) in the first 4 weeks and 100, 200, and 300 mg/kg of saffron petal extract and 10 mg/kg of lovastatin, respectively, in the second 4 weeks. At the end of the study, the level of activity of antioxidant enzymes and the level of lipid profile and inflammatory markers were measured. Results: The mean plasma MDA level, SOD enzyme activity of red blood cell, lipid profile and inflammatory markers were significantly increased in the control group (high-cholesterol diet) compared to the sham group (P <0.001). However, these cases in the other groups treated with hydroalcoholic extract of the saffron petal (groups 3, 4 and 5) and lovastatin drug (group 6) showed a significant decrease (minimum significant difference, P <0.05), despite receiving high-cholesterol diet (p<0.05) compared to the control group. Conclusion: The results of this study showed that a non-toxic dose o f saffron petal extract has an effective role in preventing cardiovascular diseases by reducing the risk factors associated with these diseases.

Item Type: Article
Creators:
CreatorsEmail
Mohamadpour, M.UNSPECIFIED
Shahmir, P.UNSPECIFIED
Asadi, M.UNSPECIFIED
Asadi, S.UNSPECIFIED
Amraei, M.UNSPECIFIED
Keywords: saffron Malondialdehyde Superoxide dismutase Inflammatory markers Rat crocus-sativus-l. hydroalcoholic extract oxidative stress lipid profile crocetin diazinon disease injury cholesterol capacity Entomology
Divisions:
Page Range: pp. 13-22
Journal or Publication Title: Entomology and Applied Science Letters
Journal Index: ISI
Volume: 7
Number: 3
ISSN: 2349-2864
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3222

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