Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis

Fri Sep 30 18:53:47 2022

(2020) Copper Concentrations in Breast Cancer: A Systematic Review and Meta-Analysis. Current Medicinal Chemistry. pp. 6373-6383. ISSN 0929-8673

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Abstract

Breast cancer is the most common neoplasm, comprising 16 of all women's cancers worldwide. Research of Copper (Cu) concentrations in various body specimens have suggested an association between Cu levels and breast cancer risks. This systematic review and meta-analysis summarize the results of published studies and examine this association. We searched the databases PubMed, Scopus, Web of Science, and Google Scholar and the reference lists of relevant publications. The Standardized Mean Differences (SMDs) between Cu levels in cancer cases and controls and corresponding Confidence Intervals (CIs), as well as I-2 statistics, were calculated to examine heterogeneity. Following the specimens used in the original studies, the Cu concentrations were examined in three subgroups: serum or plasma, breast tissue, and scalp hair. We identified 1711 relevant studies published from 1984 to 2017. There was no statistically significant difference between breast cancer cases and controls for Cu levels assayed in any studied specimen; the SMD (95 CI) was -0.01 (-1.06 - 1.03; P = 0.98) for blood or serum, 0.51 (-0.70 - 1.73; P = 0.41) for breast tissue, and -0.88 (-3.42 - 1.65; P = 0.50) for hair samples. However, the heterogeneity between studies was very high (P < 0.001) in all subgroups. We did not find evidence for publication bias (P = 0.91). The results of this meta-analysis do not support an association between Cu levels and breast cancer. However, due to high heterogeneity in the results of original studies, this conclusion needs to be confirmed by well-designed prospective studies.

Item Type: Article
Creators:
CreatorsEmail
Jouybari, L.UNSPECIFIED
Kiani, F.UNSPECIFIED
Islami, F.UNSPECIFIED
Sanagoo, A.UNSPECIFIED
Sayehmiri, F.UNSPECIFIED
Hosnedlova, B.UNSPECIFIED
Dosa, M. D.UNSPECIFIED
Kizek, R.UNSPECIFIED
Chirumbolo, S.UNSPECIFIED
Bjorklund, G.UNSPECIFIED
Keywords: Copper breast cancer women blood breast tissue hair analysis trace-elements antioxidant status serum copper risk zinc metals benign plasma tissue hair Biochemistry & Molecular Biology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 6373-6383
Journal or Publication Title: Current Medicinal Chemistry
Journal Index: ISI
Volume: 27
Number: 37
Identification Number: https://doi.org/10.2174/0929867326666190918120209
ISSN: 0929-8673
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3221

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