Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of High Expression Levels of SOX2, NANOG, and OCT4 in Gastric Cancer Tumor Tissues with Progression and Poor Prognosis

Thu Jun 20 21:23:31 2024

(2020) Association of High Expression Levels of SOX2, NANOG, and OCT4 in Gastric Cancer Tumor Tissues with Progression and Poor Prognosis. Journal of Gastrointestinal Cancer. pp. 41-47. ISSN 1941-6628

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Abstract

Background Expression of the essential regulator genes, SOX2, NANOG, and OCT4, so-called as stemness factors, is prerequisite for the tumorigenic capability of cancer stem cells (CSCs) and their potential role in the formation and progression of various human cancers. Methods In this study, the expression levels of SOX2, NANOG, and OCT4 were quantified by a qRT-PCR method in 100 gastric cancer tumor tissues vs the paired adjacent normal tissues. Then, the relationship between the expression of the three genes in gastric cancer tumor tissues and the clinicopathological characteristics and overall survival of patients was investigated. Results Higher expression levels of SOX2, NANOG, and OCT4 were found in gastric cancer tumor tissues compared with those in paired adjacent normal tissues (P = 0.0001). Overexpression of the mentioned genes in gastric cancer tumor tissues was resolved to be significantly associated with tumor size (P < 0.05), TNM stage (P = 0.001), tumor grade (P < 0.01), and shortened overall survival time (P = 0.0001). Conclusions These findings indicted that the stemness factors SOX2, NANOG, and OCT4 are significantly overexpressed in gastric cancer and may serve as potential biomarkers of gastric cancer progression and prognosis.

Item Type: Article
Creators:
CreatorsEmail
Basati, G.UNSPECIFIED
Mohammadpour, H.UNSPECIFIED
Razavi, A. E.UNSPECIFIED
Keywords: Gastric cancer Prognosis Stemness factors stem-cells Oncology Gastroenterology & Hepatology
Divisions:
Page Range: pp. 41-47
Journal or Publication Title: Journal of Gastrointestinal Cancer
Journal Index: ISI
Volume: 51
Number: 1
Identification Number: https://doi.org/10.1007/s12029-018-00200-x
ISSN: 1941-6628
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3216

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