Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models

Mon Oct 3 23:49:51 2022

(2020) Effect of Lipid Abnormality on CKD Progression from Moderate to Severe Stage: Application of Flexible Parametric Proportional-Hazards and Proportional-Odds Models. Iranian Red Crescent Medical Journal. p. 9. ISSN 2074-1804

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Abstract

Background: Lipid disorders are a well-documented risk factor for chronic kidney disease (CKD), but the impact of lipid abnormalities in the progression of the disease remains mixed. Objectives: The current study aimed to extend the existing knowledge about the effect of lipid disorders in disease progression from moderate to severe stage using Flexible parametric survival models. Methods: This retrospective cohort study included 308 moderate CKD patients who received the nephrologist follow-up visits at the nephrology clinic, Ilam (Iran), from 2012 to 2019. The survival time was determined based on the time medically diagnosed with moderate stages (GFR = 59 - 55 mL/min per 1.73 m(2)) to the time of progression to the severe stage (GFR = 29 - 25 mL/min per 1.73 m(2)) hazard using flexible parametric survival models. Results: In univariate analysis, high levels of TG, LDL, and cholesterol were important risk factors which affect the CKD progression. The hazard of patients with TG > 200 mg/dL was 1.69 times higher than patients with desirable TG levels (P = 0.09). Moreover, for patients with LDL > 160 mg/dL, the hazard was 2.12 times higher than patients with desirable LDL levels (P = 0.01). The hazard of patients with total cholesterol levels > 240 mg/dL was 2.10 times higher than patients with desirable cholesterol levels (P = 0.003). The adjusted model was shown to better fit the PH model. Cholesterol levels > 240 mg/dL remains a significant risk factor for CKD progression (P = 0.03). Conclusions: Effective treatment programs should pay closer attention to screening and treatment of hyperlipidemia in patients diagnosed with moderate CKD.

Item Type: Article
Creators:
CreatorsEmail
Mozafari, A. A.UNSPECIFIED
Mansournia, M. A.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Ghiasi, B.UNSPECIFIED
Yaseri, M.UNSPECIFIED
Azami, G.UNSPECIFIED
Keywords: Lipid Disorders Iran Flexible Parametric Model Proportional Hazards Model Proportional Odds Model chronic kidney-disease chronic-renal-failure survival models risk-factors dyslipidemia predictors dysfunction cholesterol General & Internal Medicine
Divisions:
Page Range: p. 9
Journal or Publication Title: Iranian Red Crescent Medical Journal
Journal Index: ISI
Volume: 22
Number: 7
Identification Number: https://doi.org/10.5812/ircmj.102507
ISSN: 2074-1804
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3201

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