Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

High-protein and low-calorie diets improved the anti-aging Klotho protein in the rats' brain: the toxic role of high-fat diet

Tue Oct 4 00:13:31 2022

(2020) High-protein and low-calorie diets improved the anti-aging Klotho protein in the rats' brain: the toxic role of high-fat diet. Nutrition & Metabolism. p. 12.

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Abstract

Background: In the current study, our specific aim was to characterize the Klotho protein and expression levels in the hippocampus and prefrontal cortex of old rats treated with different diets (high-fat, high-protein, low-calorie, high-protein and low-calorie). Methods: Rats were treated with high-fat, high-protein, low-calorie, low-calorie high-protein diets for 10 weeks and then behavioral and molecular assessments were evaluated. Results: Statistical analysis showed the percentage of open arm time was increased in the high-protein, low-calorie and low-calorie high-protein groups compared with old control (old-C) rats. The percentage of open arm entries was increased in the low-calorie and low-calorie high-protein group compared with old-C rats. The body weight and serum triglyceride were decreased in the low-calorie and low-calorie high-protein groups in comparison to control old rats. Low-calorie and low-calorie high-protein treatments statistically enhanced caspase-3 level compared with old-C rats in the hippocampus and prefrontal cortex. Treatment of old rats with high-protein, low-calorie and low-calorie high-protein could increase Klotho-alpha level compared with control old rats. The levels of Klotho-alpha, c-fos and brain-derived neurotrophic factors were decreased in the low-calorie high-protein group in Klotho inhibitor's presence compared with the low-calorie high-protein group. Conclusion: According to our findings, Klotho-alpha level was reduced in old rats. Low-calorie, high-protein and particularly low-calorie high-protein diets increased this protein level and consequently increased neuronal plasticity and improved memory function.

Item Type: Article
Creators:
CreatorsEmail
Shafie, A.UNSPECIFIED
Rahimi, A. M.UNSPECIFIED
Ahmadi, I.UNSPECIFIED
Nabavizadeh, F.UNSPECIFIED
Ranjbaran, M.UNSPECIFIED
Ashabi, G.UNSPECIFIED
Keywords: Klotho FGF23 c-fos High-protein diet Low-calorie diet low-carbohydrate energy-intake stress impact model mice hippocampus obesity target Nutrition & Dietetics
Divisions:
Page Range: p. 12
Journal or Publication Title: Nutrition & Metabolism
Journal Index: ISI
Volume: 17
Number: 1
Identification Number: https://doi.org/10.1186/s12986-020-00508-1
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3183

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