Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Strategies in DNA vaccine for melanoma cancer

Sat Jul 20 20:20:30 2024

(2020) Strategies in DNA vaccine for melanoma cancer. Pigment Cell & Melanoma Research. p. 23. ISSN 1755-1471

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According to reports of the international agency for cancer on research, although malignant melanoma shows less prevalence than nonmelanoma skin cancers, it is the major cause of skin cancer mortality. Given that, the production of effective vaccines to control melanoma is eminently required. In this regard, DNA-based vaccines have been extensively investigated for melanoma therapy. DNA vaccines are capable of inducing both cellular and humoral branches of immune responses. These vaccines possess some valuable advantages such as lack of severe side effects and high stability compared to conventional vaccination methods. The ongoing studies are focused on novel strategies in the development of DNA vaccines encoding artificial polyepitope immunogens based on the multiple melanoma antigens, the inclusion of molecular adjuvants to increase the level of immune responses, and the improvement of delivery approaches. In this review, we have outlined the recent advances in the field of melanoma DNA vaccines and described their implications in clinical trials as a strong strategy in the prevention and control of melanoma.

Item Type: Article
de la Guardia, M.UNSPECIFIED
Mokhtarzadeh, A.UNSPECIFIED
Keywords: clinical approaches DNA vaccine melanoma melanoma antigens therapeutic antitumor immunity t-cell responses metastatic melanoma malignant-melanoma suppressor-cells dendritic cells tumor-growth delivery antigen efficacy Oncology Cell Biology Dermatology
Page Range: p. 23
Journal or Publication Title: Pigment Cell & Melanoma Research
Journal Index: ISI
Identification Number:
ISSN: 1755-1471
Depositing User: مهندس مهدی شریفی

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